FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Ecol\lacZsc.3.7+5.7
Open Close
General Information
Symbol
Ecol\lacZsc.3.7+5.7
Species
E. coli
Name
FlyBase ID
FBal0047878
Feature type
allele
Associated gene
Ecol\lacZ
Associated Insertion(s)
Carried in Construct
P{ac/sc3.7+5.7}
Transgenic product class
Mutagen
Nature of the Allele
Transgenic product class
Mutagen
in vitro construct
(Cubadda et al., 1997, Haenlin et al., 1997, Gomez-Skarmeta et al., 1995)
Progenitor genotype
Ecol\lacZsc.3.7
(Gomez-Skarmeta et al., 1995)
Carried in construct
P{ac/sc3.7+5.7}
Cytology
Description

5.7kb EcoRI fragment containing the dorsocentral enhancer from the ac-sc region is fused upstream of a 3.7kb sc promoter fragment driving expression of a lacZ reporter.

(Cubadda et al., 1997)

5.7kb EcoRI fragment containing the dorsocentral enhancer is fused upstream of a 3.7kb sc promoter fragment driving expression of a lacZ reporter.

(Haenlin et al., 1997)

5.7kb EcoRI fragment, from position 68.6 to 62.9 on the AS-C map, containing an enhancer for the dorsocentral (DC) cluster, is ligated upstream of the sc promoter fragment of Ecol\lacZsc.3.7.

(Gomez-Skarmeta et al., 1995)
Allele components
Component
Use(s)
Regulatory region(s)
sc_DC
Encoded product / tool
lacZ
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      distribution deduced from reporter
      Stage
      Tissue/Position (including subcellular localization)
      Reference
      third instar larval stage
      proneural cluster | subset
      (Tomoyasu et al., 1998)
      external sensory organ precursor cell | subset
      (Tomoyasu et al., 1998)
      sensory mother cell | subset
      (Tomoyasu et al., 1998)
      wing sensillum | precursor
      (Gomez-Skarmeta et al., 1995)
      wing disc | restricted
      (Gomez-Skarmeta et al., 1995)
      dorsocentral bristle | presumptive
      (Tomoyasu et al., 1998, Gomez-Skarmeta et al., 1995)
      prescutum | presumptive
      (Gomez-Skarmeta et al., 1995)
      mesothoracic postnotum | presumptive
      (Gomez-Skarmeta et al., 1995)
      Additional Information
      Statement
      Reference

      Expression is observed in the precursor cells of the dorsocentral bristles.

      (Tomoyasu et al., 1998)

      In third instar wing disc, expression of EcollacZsc.3.7RA (serves as control), plus additional elements in the notal region of the disc; these additional regions of expression correspond to cells that give rise to the dorsocentral bristles (dc), to a region of the prescutum and to a region of the postnotum.

      (Gomez-Skarmeta et al., 1995)
       
      Marker for
      proneural cluster
      (Tomoyasu et al., 1998)
      Reflects expression of
      sc
      (Tomoyasu et al., 1998)
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (2)
      Reported As
      Symbol Synonym
      Ecol\lacZsc.3.7+5.7
      lacZsc.3.7+5.7
      Name Synonyms
      Secondary FlyBase IDs
        References (6)