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General Information
Symbol
Dmel\KhcBD
Species
D. melanogaster
Name
FlyBase ID
FBal0048833
Feature type
allele
Associated gene
Associated Insertion(s)
Carried in Construct
Key Links
Nature of the Allele
Mutations Mapped to the Genome
 
Type
Location
Additional Notes
References
Associated Sequence Data
DNA sequence
Protein sequence
 
 
Progenitor genotype
Cytology
Nature of the lesion
Statement
Reference
Expression Data
Reporter Expression
Additional Information
Statement
Reference
 
Marker for
Reflects expression of
Reporter construct used in assay
Human Disease Associations
Disease Ontology (DO) Annotations
Models Based on Experimental Evidence ( 0 )
Disease
Evidence
References
Modifiers Based on Experimental Evidence ( 0 )
Disease
Interaction
References
Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
 
Disease-implicated variant(s)
 
Phenotypic Data
Phenotypic Class
Phenotype Manifest In
Detailed Description
Statement
Reference

Mutation causes organelle-filled axonal swellings that exhibit abnormal accumulation of nerve terminal proteins, including syt.

Khc6/KhcBD heteroallelic flies cultured at 22oC become paralysed at 39oC. The temperature threshold for this behavior is higher than that for mlenap-ts1 or parats1, and the timecourse of recovery is slower. For many minutes the flies remain sluggish. Shows no bang sensitivity.

External Data
Interactions
Show genetic interaction network for Enhancers & Suppressors
Phenotypic Class
Suppressor of
Statement
Reference

Khc6/KhcBD is a suppressor of abnormal behavior | recessive phenotype of eag1

Khc6/KhcBD is a suppressor of abnormal behavior phenotype of Sh14

Other
Statement
Reference
Phenotype Manifest In
Suppressor of
Statement
Reference

Khc6/KhcBD is a suppressor of leg phenotype of eag1

Khc6/KhcBD is a suppressor of leg phenotype of Sh14

Additional Comments
Genetic Interactions
Statement
Reference

Khc6/KhcBD suppresses the leg shaking of Sh14 and eag1 mutants, and this phenotype is reversed by addition of one copy of Khc+t7.5.

Xenogenetic Interactions
Statement
Reference
Complementation and Rescue Data
Rescued by
Comments

The paralysis of Khc6/KhcBD flies at 39oC is rescued by one copy of Khc+t7.5.

Images (0)
Mutant
Wild-type
Stocks (0)
Notes on Origin
Discoverer
External Crossreferences and Linkouts ( 0 )
Synonyms and Secondary IDs (2)
Reported As
Symbol Synonym
2-60
KhcBD
Name Synonyms
Secondary FlyBase IDs
    References (2)