FlyBase Allele Report: Dmel\caup[1]

General Information

Symbol

Dmel\caup¹

Species

D. melanogaster

Name

FlyBase ID

FBal0049382

Feature type

allele

Associated gene

Dmel\caup

Associated Insertion(s)

Carried in Construct

Also Known As

iro¹

Key Links

Allele class

loss of function allele

amorphic allele - genetic evidence

Mutagen

X ray

Nature of the Allele

Allele class

amorphic allele - genetic evidence

(Gomez-Skarmeta et al., 1996)

loss of function allele

(Fujise et al., 2001)

Mutagen

X ray

(Leyns et al., 1996, Dambly-Chaudiere and Leyns, 1992)

Progenitor genotype

Caused by aberration

Tp(3;3)iro-1

Cytology

Description

Transposition deletion breakpoint maps to an intron between the first and second exons in the protein coding region of the caup transcription unit.

(Gomez-Skarmeta et al., 1996)

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

female sterile | recessive

(Leyns et al., 1996)

male sterile | recessive

(Leyns et al., 1996)

viable

(Leyns et al., 1996, Dambly-Chaudiere and Leyns, 1992)

visible

(Leyns et al., 1996, Dambly-Chaudiere and Leyns, 1992)

Phenotype Manifest In

macrochaeta

(Leyns et al., 1996)

macrochaeta & scutum

(Dambly-Chaudiere and Leyns, 1992)

mesothoracic segment

(Leyns et al., 1996)

microchaeta

(Leyns et al., 1996)

notopleural suture

(Leyns et al., 1996)

scutellum

(Leyns et al., 1996)

wing

(Leyns et al., 1996)

Detailed Description

Statement

Reference

Heterozygotes have a very mild phenotype with some thoracic bristles occasionally being missing. Double heterozygotes with Df(4)M101-62f or Df(1)260-1 have a much stronger phenotype, with some bristles missing at a high frequency. Homozygotes lack all bristles on the lateral part of the notum, so that only a median stripe of bristles remains. The mesothorax is narrower than normal, and has no notopleural suture. The scutellum is smaller than normal, and the wings are raised. caup¹/Df(3L)iro-2 flies are viable and have a phenotype similar to caup¹ homozygotes. caup¹/caup¹ flies carrying sc^hs.PR develop tufts of bristles in the lateral part of the notum (that is normally naked in caup¹ homozygotes) after heat shock.

(Leyns et al., 1996)

Only the median strip of hairs remains on the notum.

(Dambly-Chaudiere and Leyns, 1992)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Other

Statement

Reference

Df(3L)iro-2, ac^Hw-49c, ara¹, caup¹ has visible phenotype

(Grillenzoni et al., 1998)

Df(3L)iro-2, ara¹, caup¹ has visible | recessive phenotype

(Grillenzoni et al., 1998)

Df(3L)iro-2, ac^Hw-49c, ara¹, caup¹ has visible | recessive phenotype

(Grillenzoni et al., 1998)

Phenotype Manifest In

Other

Statement

Reference

Df(3L)iro-2, ac^Hw-49c, ara¹, caup¹ has mesothoracic bristle | lateral phenotype

(Grillenzoni et al., 1998)

Df(3L)iro-2, ara¹, caup¹ has postpronotum phenotype

(Grillenzoni et al., 1998)

Df(3L)iro-2, ara¹, caup¹ has mesothoracic bristle | lateral phenotype

(Grillenzoni et al., 1998)

Df(3L)iro-2, ara¹, caup¹ has scutum & microchaeta | lateral phenotype

(Grillenzoni et al., 1998)

Additional Comments

Genetic Interactions

Statement

Reference

ara¹ caup¹/Df(3L)iro-2 flies lack lateral macrochaetae and the most lateral of microchaetae of the notum. The humeral bristles are normal and have wild-type axonal projections in these flies although the humerus is not morphologically normal. Bristles of variable size are formed in the otherwise naked lateral region of the notum if the flies are also carrying ac^Hw-49c, at a position corresponding to that of the posterior supraalar bristle. This bristle has a contralateral axon branch in about 70% of cases.

(Grillenzoni et al., 1998)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

Comments

Isolated as a mutation that alters the pattern of bristles when doubly heterozygous with Df(4)M101-62f.

(Leyns et al., 1996)

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (4)

Reported As

Symbol Synonym

caup¹

caup^L19

iro¹

(Letizia et al., 2007, Fujise et al., 2001, Sato et al., 1999, Grillenzoni et al., 1998, Gomez-Skarmeta et al., 1996, Leyns et al., 1996, Santaren and Garcia-Bellido, 1996)

iro^L19

(Dambly-Chaudiere and Leyns, 1992)

Name Synonyms

Secondary FlyBase IDs

References (9)

Report Sections

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