FB2026_03 , released September 17, 2026
Allele: Dmel\ewghs.PD
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General Information
Symbol
Dmel\ewghs.PD
Species
D. melanogaster
Name
heat shock construct of DeSimone
FlyBase ID
FBal0049488
Feature type
allele
Associated gene
Dmel\ewg
Associated Insertion(s)
Carried in Construct
P{ewgHS1}
Key Links
Transgenic product class
cDNA
(de Simone and White, 1993)
wild_type
(de Simone and White, 1993)
Mutagen
Nature of the Allele
Transgenic product class
cDNA
(de Simone and White, 1993)
wild_type
(de Simone and White, 1993)
Mutagen
in vitro construct
(DeSimone et al., 1996, de Simone and White, 1993)
Progenitor genotype
Carried in construct
P{ewgHS1}
Cytology
Description

An Hsp70 promoter drives expression of a 4.8kb SC3 ewg cDNA.

(de Simone and White, 1993)
Allele components
Component
Use(s)
Regulatory region(s)
Hsp70
Encoded product / tool
ewg
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Flies carrying two copies of P{ewgHS1} in an otherwise wild-type background show reduced viability at 25oC. The effect is more marked for males than females.

      (Koushika et al., 1999)

      Basal expression can rescue the embryonic lethality associated with loss of ewg function (FBrf0059052) and the IFM defects.

      (DeSimone et al., 1996)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Rescues

      ewghs.PD rescues ewg10

      (de Simone and White, 1993)

      ewghs.PD rescues ewg11

      (de Simone and White, 1993)

      ewghs.PD rescues ewg2

      (de Simone and White, 1993)

      ewghs.PD rescues ewg4

      (de Simone and White, 1993)

      ewghs.PD rescues ewg5

      (de Simone and White, 1993)
      Partially rescues

      ewghs.PD partially rescues ewg1

      (de Simone and White, 1993)
      Comments

      ewghs.PD rescues lethality associated with ewg2, ewg4, ewg5, ewg10 and ewg11, and the erect wing phenotype of ewg1.

      (de Simone and White, 1993)
      Images (0)
      Mutant
      Wild-type
      Stocks (1)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (2)
      Reported As
      Symbol Synonym
      ewghs.PD
      Name Synonyms
      heat shock construct of DeSimone
      (DeSimone et al., 1996)
      Secondary FlyBase IDs
        References (3)