FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\ksrS-721
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General Information
Symbol
Dmel\ksrS-721
Species
D. melanogaster
Name
FlyBase ID
FBal0049703
Feature type
allele
Associated gene
Dmel\ksr
Associated Insertion(s)
Carried in Construct
Key Links
Genomic Maps

Allele class

loss of function allele

Mutagen
    Nature of the Allele
    Allele class

    loss of function allele

    (Therrien et al., 1995)
    Mutagen
    Progenitor genotype
    Cytology
    Description

    10bp insertion in the codon for N727 within kinase subdomain III causing a frameshift mutation that truncates the protein at kinase subdomain III.

    (Therrien et al., 1995)
    Mutations Mapped to the Genome
    Curation Data
    Type
    Location
    Additional Notes
    References
    insertion
    3R:5,481,458..5,481,459 [-]
    Comment:

    A 10bp insertion in codon N727 creates a frameshift and leads to early translation termination in kinase subdomain III. The exact site of the insertion was not specified and has been annotated between the first and second base of the codon.

    (Therrien et al., 1995)
    Variant Molecular Consequences
    Associated Sequence Data
    DDBJ / EMBL / GenBank
    DNA sequence
    Protein sequence
     
    UniProtKB/Swiss-Prot
      UniProtKB/TrEMBL
        Expression Data
        Reporter Expression
        Additional Information
        Statement
        Reference
         
        Marker for
        Reflects expression of
        Reporter construct used in assay
        Human Disease Associations
        Disease Ontology (DO) Annotations
        Models Based on Experimental Evidence ( 0 )
        Disease
        Evidence
        References
        Modifiers Based on Experimental Evidence ( 0 )
        Disease
        Interaction
        References
        Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
         
        Disease-implicated variant(s)
         
        Phenotypic Data
        Phenotypic Class
        Phenotype Manifest In
        Detailed Description
        Statement
        Reference
        External Data
        Interactions
        Show genetic interaction network for Enhancers & Suppressors
        Phenotypic Class
        Phenotype Manifest In
        Suppressor of
        Statement
        Reference

        ksrS-721 is a suppressor of eye phenotype of Ras85DV12.sev

        (Therrien et al., 1995)
        Additional Comments
        Genetic Interactions
        Statement
        Reference

        Dominantly suppresses the rough eye phenotype of Ras85DV12.sev.

        (Therrien et al., 1995)
        Xenogenetic Interactions
        Statement
        Reference
        Complementation and Rescue Data
        Comments
        Images (0)
        Mutant
        Wild-type
        Stocks (0)
        Notes on Origin
        Discoverer
        External Crossreferences and Linkouts ( 0 )
        Synonyms and Secondary IDs (1)
        Reported As
        Symbol Synonym
        ksrS-721
        Name Synonyms
        Secondary FlyBase IDs
          References (1)