FlyBase Allele Report: Dmel\mib1[3]

General Information

Symbol

Dmel\mib1³

Species

D. melanogaster

Name

FlyBase ID

FBal0049847

Feature type

allele

Associated gene

Dmel\mib1

Associated Insertion(s)

Carried in Construct

Key Links

Allele class

loss of function allele

Mutagen

Nature of the Allele

Allele class

loss of function allele

(Le Borgne et al., 2005)

Mutagen

Progenitor genotype

Cytology

Description

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

lethal | recessive

(Melendez et al., 1995)

lethal - all die before end of pupal stage (with Df(3L)mib1²)

(Le Borgne et al., 2005)

lethal - all die before end of pupal stage (with mib1^EY09780)

(Le Borgne et al., 2005)

some die during pupal stage (with Df(3L)mib1²)

(Le Borgne et al., 2005)

some die during pupal stage (with mib1^EY09780)

(Le Borgne et al., 2005)

visible (with Df(3L)mib1²)

(Hamel et al., 2010)

visible (with mib1⁴)

(Hamel et al., 2010)

Phenotype Manifest In

wing (with Df(3L)mib1²)

(Hamel et al., 2010)

wing (with mib1⁴)

(Hamel et al., 2010)

wing disc (with mib1^EY09780)

(Le Borgne et al., 2005)

Detailed Description

Statement

Reference

Df(3L)mib1²/mib1³ animals show a strong wing loss phenotype.

11% of mib1³/mib1⁴ flies show a wing nicking phenotype.

(Hamel et al., 2010)

Mutant testes have an abundance of mature primary spermatocytes with chromosome condensation.

(Le Borgne et al., 2005)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Suppressed by

Statement

Reference

mib1⁴/mib1³ has visible phenotype, suppressible by α4GT1^GS2078/Scer\GAL4^Ser.PGF

(Hamel et al., 2010)

NOT suppressed by

Statement

Reference

mib1³/Df(3L)mib1² has visible phenotype, non-suppressible by α4GT1^GS2078/Scer\GAL4^Ser.PGF

(Hamel et al., 2010)

Phenotype Manifest In

Suppressed by

Statement

Reference

mib1⁴/mib1³ has wing phenotype, suppressible by α4GT1^GS2078/Scer\GAL4^Ser.PGF

(Hamel et al., 2010)

mib1³/mib1^EY09780 has wing disc phenotype, suppressible by N^{FLN.ΔCdc10.UAS}/Scer\GAL4^Ser.PGF

(Le Borgne et al., 2005)

mib1³/mib1^EY09780 has wing disc phenotype, suppressible by Scer\GAL4^Ser.PGF/neur^UAS.cPa

(Le Borgne et al., 2005)

NOT suppressed by

Statement

Reference

mib1³/Df(3L)mib1² has wing phenotype, non-suppressible by α4GT1^GS2078/Scer\GAL4^Ser.PGF

(Hamel et al., 2010)

mib1³/mib1^EY09780 has wing disc phenotype, non-suppressible by Scer\GAL4^Ser.PGF/Ser^UAS.cSa

(Le Borgne et al., 2005)

Additional Comments

Genetic Interactions

Statement

Reference

The penetrance of the wing nicking phenotype seen in mib1³/mib1⁴ flies is decreased to 1% if they are also expressing α4GT1^GS2078 under the control of Scer\GAL4^Ser.PGF post-embryonically (animals are transferred to 28[o]C after embryogenesis to inactivate Scer\GAL80^ts.αTub84B which is present in the stock).

The wing phenotype of Df(3L)mib1²/mib1³ flies is not modified by expression of α4GT1^GS2078 under the control of Scer\GAL4^Ser.PGF post-embryonically (animals are transferred to 28[o]C after embryogenesis to inactivate Scer\GAL80^ts.αTub84B which is present in the stock).

(Hamel et al., 2010)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Fails to complement

mib1^EY09780

(Le Borgne et al., 2005)

Rescued by

mib1³/Df(3L)mib1² is rescued by mib1^UAS.YFP/Scer\GAL4^Ser.PGF

(Le Borgne et al., 2005)

mib1³/Df(3L)mib1² is rescued by mib1^UAS.cLa/Scer\GAL4^Ser.PGF

(Le Borgne et al., 2005)

Comments

Images (0)

Mutant

Wild-type

Stocks (1)

Bloomington

99572

w¹¹¹⁸; mib1³ P{white-un4}71F/TM3, Sb¹

Notes on Origin

Discoverer

Comments

7 alleles isolated in a screen devised to recover lethal mutations uncovered by Df(3L)brm11.

(Melendez et al., 1995)

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (5)

Reported As

Symbol Synonym

l(3)72CDa^J12

(Bloomington Drosophila Stock Center, 1997.12.5)

l(3)72Cda^J12

(Le Borgne et al., 2005)

mib1³

(Hamel et al., 2010)

mind-bomb³

unspecified

(Melendez et al., 1995)

Name Synonyms

Secondary FlyBase IDs

References (4)

Report Sections

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