FlyBase Allele Report: Dmel\lz[Sprite]

General Information

Symbol

Dmel\lz^Sprite

Species

D. melanogaster

Name

FlyBase ID

FBal0050114

Feature type

allele

Associated gene

Dmel\lz

Associated Insertion(s)

P{scrt.sE}lz^Sprite

Carried in Construct

Key Links

Genomic Maps

JBrowse

Allele class

gain of function allele

Mutagen

P-element activity

Nature of the Allele

Allele class

gain of function allele

(Flores et al., 1998, Daga et al., 1996)

Mutagen

P-element activity

(Daga et al., 1996)

Progenitor genotype

Associated Insertion(s)

P{scrt.sE}lz^Sprite

Cytology

Description

P-element insertion in the 3' untranslated lz sequences.

(Daga et al., 1996)

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

transposable_element_insertion_site

X:9,305,990..9,305,990

(Jackson Behan et al., 2005, Daga et al., 1996)

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

viable

(Daga et al., 1996)

visible | dominant

(Daga et al., 1996)

Phenotype Manifest In

photoreceptor cell R1 & axon

(Clandinin and Zipursky, 2000)

photoreceptor cell R2 & axon

(Clandinin and Zipursky, 2000)

photoreceptor cell R3

(Clandinin and Zipursky, 2000, Flores et al., 1998, Daga et al., 1996)

photoreceptor cell R4

(Clandinin and Zipursky, 2000, Flores et al., 1998, Daga et al., 1996)

photoreceptor cell R5 & axon

(Clandinin and Zipursky, 2000)

photoreceptor cell R6 & axon

(Clandinin and Zipursky, 2000)

Detailed Description

Statement

Reference

R3 and R4 are transformed to R7 cells. In completely transformed ommatidia the relative positions of the targets chosen by R1, R2, R5 and R6 are frequently highly aberrant. Ommatidia are normally rotated.

(Clandinin and Zipursky, 2000)

The presumptive R3/R4 photoreceptor cells differentiate as R7 cells in flies carrying lz^Sprite.

(Flores et al., 1998)

Conversion of outer photoreceptor neurons R3 and R4 to ventral R7-like photoreceptor, a dosage sensitive phenotype (R4 is more sensitive to conversion than R3). The fate of these R7-like cells is partially dependent on sev function, in a sev¹⁴ background many R7-like cells fail to develop as photoreceptor neurons. sev¹⁴, lz^Sprite double mutants display wild-type phototactic behaviour (migrate towards the UV light source) demonstrating the converted R7-like cells function as R7 photoreceptors. In a Ras85D^e1B background most ommatidia have lost at least one photoreceptor cell. lz^r1/lz⁺; P{sevRas1.V12} flies display an external roughening of the eye and the conversion of three to four cone cells in each ommatidia to R7 cells, this phenotype is indistinguishable from P{sevRas1.V12} alone.

(Daga et al., 1996)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Suppressor of

Statement

Reference

lz^Sprite is a suppressor of visible phenotype of aop^ACT.GMR

(Behan et al., 2002)

Phenotype Manifest In

Suppressor of

Statement

Reference

lz^Sprite is a suppressor of eye phenotype of aop^ACT.GMR

(Behan et al., 2002)

Additional Comments

Genetic Interactions

Statement

Reference

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (3)

Reported As

Symbol Synonym

lz^Sprite

lz^spr

(Clandinin and Zipursky, 2000)

lz^sprite

(Jackson Behan et al., 2005, Behan et al., 2002, Kaminker et al., 2001)

Name Synonyms

Secondary FlyBase IDs

References (6)

Report Sections

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