FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\spdoK433
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General Information
Symbol
Dmel\spdoK433
Species
D. melanogaster
Name
FlyBase ID
FBal0050555
Feature type
allele
Associated gene
Dmel\spdo
Associated Insertion(s)
Carried in Construct
Key Links
Genomic Maps

Allele class

loss of function allele

Mutagen
Nature of the Allele
Allele class

loss of function allele

(Dye et al., 1998, Salzberg et al., 1994)
Mutagen
ethyl methanesulfonate
(Salzberg et al., 1994)
Progenitor genotype
Cytology
Description

Amino acid replacement: S468F.

(Skeath, 2005.2.14)

Amino acid replacement: S??.

(O'Connor-Giles and Skeath, 2003)
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
point_mutation
3R:30,478,294..30,478,294 [+]
Nucleotide change:

C30478294T

Amino acid change:

S468F | spdo-PA

Reported amino acid change:

S468F

Comment:

Site of nucleotide substitution in mutant inferred by FlyBase based on reported amino acid change.

(Skeath, 2005.2.14, O'Connor-Giles and Skeath, 2003)
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In

      abdominal 1 basiconical sensillum dbd & embryonic glial cell

      (Dye et al., 1998)

      abdominal 1 dorsal bipolar neuron dbp

      (Dye et al., 1998)

      abdominal 2 basiconical sensillum dbd & embryonic glial cell

      (Dye et al., 1998)

      abdominal 2 dorsal bipolar neuron dbp

      (Dye et al., 1998)

      abdominal 3 basiconical sensillum dbd & embryonic glial cell

      (Dye et al., 1998)

      abdominal 3 dorsal bipolar neuron dbp

      (Dye et al., 1998)

      abdominal 4 basiconical sensillum dbd & embryonic glial cell

      (Dye et al., 1998)

      abdominal 4 dorsal bipolar neuron dbp

      (Dye et al., 1998)

      abdominal 5 basiconical sensillum dbd & embryonic glial cell

      (Dye et al., 1998)

      abdominal 5 dorsal bipolar neuron dbp

      (Dye et al., 1998)

      abdominal 6 basiconical sensillum dbd & embryonic glial cell

      (Dye et al., 1998)

      abdominal 6 dorsal bipolar neuron dbp

      (Dye et al., 1998)

      abdominal 7 basiconical sensillum dbd & embryonic glial cell

      (Dye et al., 1998)

      abdominal 7 dorsal bipolar neuron dbp

      (Dye et al., 1998)

      CNS glial cell

      (Dye et al., 1998)

      external sensory organ

      (Dye et al., 1998)

      external sensory organ precursor cell IIb

      (Dye et al., 1998)

      larval anterior commissure

      (Dye et al., 1998)

      larval longitudinal connective

      (Dye et al., 1998)

      larval pericardial cell

      (Park et al., 1998)

      larval posterior commissure

      (Dye et al., 1998)

      multidendritic neuron

      (Dye et al., 1998)

      multidendritic neuron | precursor

      (Dye et al., 1998)

      muscle cell of abdominal 1 dorsal acute muscle 3

      (Crozatier and Vincent, 1999)

      muscle cell of abdominal 1 dorsal oblique muscle 5

      (Crozatier and Vincent, 1999)

      muscle cell of abdominal 2 dorsal acute muscle 3

      (Crozatier and Vincent, 1999)

      muscle cell of abdominal 2 dorsal oblique muscle 5

      (Crozatier and Vincent, 1999)

      muscle cell of abdominal 3 dorsal acute muscle 3

      (Crozatier and Vincent, 1999)

      muscle cell of abdominal 3 dorsal oblique muscle 5

      (Crozatier and Vincent, 1999)

      muscle cell of abdominal 4 dorsal acute muscle 3

      (Crozatier and Vincent, 1999)

      muscle cell of abdominal 4 dorsal oblique muscle 5

      (Crozatier and Vincent, 1999)

      muscle cell of abdominal 5 dorsal acute muscle 3

      (Crozatier and Vincent, 1999)

      muscle cell of abdominal 5 dorsal oblique muscle 5

      (Crozatier and Vincent, 1999)

      muscle cell of abdominal 6 dorsal acute muscle 3

      (Crozatier and Vincent, 1999)

      muscle cell of abdominal 6 dorsal oblique muscle 5

      (Crozatier and Vincent, 1999)

      muscle cell of abdominal 7 dorsal acute muscle 3

      (Crozatier and Vincent, 1999)

      muscle cell of abdominal 7 dorsal oblique muscle 5

      (Crozatier and Vincent, 1999)

      peripheral nervous system

      (Dye et al., 1998)

      thecogen cell

      (Dye et al., 1998)

      thecogen cell & peripheral nervous system

      (Salzberg et al., 1994)
      Detailed Description
      Statement
      Reference

      In mutant embryos the DA3A muscle is duplicated at the expense of DO5A in most segments.

      (Crozatier and Vincent, 1999)

      Shows severe phenotype in trans to Df(3R)tll-g. spdo embryos display an approximate doubling of the number of neurons in the PNS, though the neurons are distributed among the four typical clusters in each segment and the overall morphology of the embryos is not affected. The two sibling cells of SOPIIb take the same, neuronal, fate. The md neurons are also increased in number, as are the dbd neurons. The dbd neuron is duplicated at the expense of its glial cell. For those neurons that have a lineage-related sibling, the non-neuronal cells adopt a neuronal fate in spdo mutants. Marker expression suggests that es neurons are transformed to md neurons in spdo mutants, similar to the transformation in N mutants. Lack of spdo causes a severe lack of glial cells in the CNS. The longitudinal tracts of the CNS are disrupted. The anterior and posterior commissures appear thicker and less condensed than normal.

      (Dye et al., 1998)

      eve-expressing pericardial cells are almost completely absent in Df(3R)ZZ27/spdoK433 embryos, although the presence of the DA1 muscles is unaffected.

      (Park et al., 1998)

      Defect in embryonic PNS development: gain of neurons, glial support cells are transformed into neurons.

      (Salzberg et al., 1994)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Fails to complement

      spdoH7

      (Dye et al., 1998)
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (1)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (1)
      Reported As
      Symbol Synonym
      spdoK433
      Name Synonyms
      Secondary FlyBase IDs
        References (8)