FlyBase Allele Report: Dmel\spdo[H7]

General Information

Symbol

Dmel\spdo^H7

Species

D. melanogaster

Name

FlyBase ID

FBal0220942

Feature type

allele

Associated gene

Dmel\spdo

Associated Insertion(s)

Carried in Construct

Key Links

Allele class

loss of function allele

Mutagen

Nature of the Allele

Allele class

loss of function allele

(Dye et al., 1998)

Mutagen

Progenitor genotype

P{lacW}Y1444

(Dye et al., 1998)

Cytology

Description

This allele may be caused by a deficiency associated with the insertion P{lacW}tmod^H7 which deletes the spdo gene - possibly extending to the insertion site of P{lacW}Y1444.

(Skeath, 2004)

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

lethal - all die during embryonic stage

(Dye et al., 1998)

some die during embryonic stage

(Dye et al., 1998)

Phenotype Manifest In

embryonic peripheral nervous system & glial cell

(Dye et al., 1998)

peripheral nervous system precursor cluster

(Dye et al., 1998)

peripheral nervous system precursor cluster & neuron | supernumerary

(Dye et al., 1998)

Detailed Description

Statement

Reference

Shows severe phenotype in trans to Df(3R)tll-g. spdo^H7 embryos display an approximate doubling of the number of neurons in the PNS, though the neurons are distributed among the four typical clusters in each segment and the overall morphology of the embryos is not affected. Glial cells associated with these clusters are missing.

(Dye et al., 1998)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Phenotype Manifest In

Suppressed by

Statement

Reference

spdo^H7 has embryonic peripheral nervous system & glial cell | supernumerary phenotype, suppressible by tmod^hs.PDL

(Dye et al., 1998)

Suppressor of

Statement

Reference

spdo^H7 is a suppressor of embryonic peripheral nervous system & neuron phenotype of numb¹

(Dye et al., 1998)

spdo^H7 is a suppressor of abdominal dorsal bipolar neuron dbp | embryonic stage phenotype of numb¹

(Dye et al., 1998)

spdo^H7 is a suppressor of embryonic peripheral nervous system & glial cell | supernumerary phenotype of numb¹

(Dye et al., 1998)

Additional Comments

Genetic Interactions

Statement

Reference

The phenotype of double mutants with numb¹ does not resemble the numb¹ phenotype, but the spdo mutant phenotype. tmod^hs.PDL partially suppresses the loss of pros expressing glial cells in the embryonic peripheral nervous system of spdo^H7 embryos. The phenotype of double mutants with spdo^H7 does not resemble the numb¹ phenotype, but the spdo mutant phenotype. In the absence of numb two dbd glial cells are seen. In double mutants with spdo^H7, the dbd glial cell is missing, as for spdo mutants. spdo^H7/spdo^H7 largely suppresses the reduction in neuron numbers seen in stage 15 numb¹ homozygous embryos.

(Dye et al., 1998)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Fails to complement

spdo^G104

(Dye et al., 1998)

spdo^K433

(Dye et al., 1998)

spdo^C55

(Dye et al., 1998)

Comments

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

Associated with: tmod^H7.

(FlyBase, 1996-)

Associated with: tmod^H7

Evidence suggests that the "H7" chromosome contains lesions that affect both tmod and spdo (as suggested in FBrf0182569 and FBrf0183486); the P{lacW}tmod^H7 insertion maps within the tmod transcription unit (see FBrf0102830) and the "H7" chromosome also fails to complement spdo mutations, suggesting that there is a second lesion that affects spdo. The nature of the lesion(s) is not known, however data from FBrf0183486 suggests that there may be a deletion extending from the site of the progenitor insertion to the P{lacW}tmod^H7 insertion in tmod.

(FlyBase, 1996-)

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (1)

Reported As

Symbol Synonym

spdo^H7

Name Synonyms

Secondary FlyBase IDs

FBal0046512

References (4)

Report Sections

Open Close