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General Information
Symbol
Dmel\ttkB330
Species
D. melanogaster
Name
FlyBase ID
FBal0050675
Feature type
allele
Associated gene
Associated Insertion(s)
Carried in Construct
Key Links
Nature of the Allele
Mutations Mapped to the Genome
 
Type
Location
Additional Notes
References
Associated Sequence Data
DNA sequence
Protein sequence
 
 
Progenitor genotype
Cytology
Nature of the lesion
Statement
Reference
Expression Data
Reporter Expression
Additional Information
Statement
Reference
 
Marker for
Reflects expression of
Reporter construct used in assay
Human Disease Associations
Disease Ontology (DO) Annotations
Models Based on Experimental Evidence ( 0 )
Disease
Evidence
References
Modifiers Based on Experimental Evidence ( 0 )
Disease
Interaction
References
Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
 
Disease-implicated variant(s)
 
Phenotypic Data
Phenotypic Class
Phenotype Manifest In

thecogen cell & peripheral nervous system

Detailed Description
Statement
Reference

Lateral glial cells are present but they fail to organise into the regular pattern seen in wild type embryos. In the CNS of stage 16 embryos the number of lateral glial cells is reduced by about 20%. Midline glial cells are still specified but fail to properly differentiate and instead of migrating between the two segmental commissures that remain anterior to the commissures which subsequently appear fused. In stage 16 embryos the midline glial cells start to degenerate and are cleared from the nervous system. pnt ttk double mutant flies display an additive CNS phenotype combining characteristics of both phenotypic traits.

Defect in embryonic PNS development: gain of neurons, outer support cells are transformed into the lineage-related neuron and glia.

External Data
Interactions
Show genetic interaction network for Enhancers & Suppressors
Phenotypic Class
Suppressor of
Phenotype Manifest In
Additional Comments
Genetic Interactions
Statement
Reference

ttkB330 has minor effects on the neuronal defects seen in embryos expressing gcmScer\UAS.cHa under the control of Scer\GAL4sca-T3.

The partial lethality due to runScer\UAS.cLa; Scer\GAL4nos.PG (3% viable) is partially suppressed by maternal heterozygosity for ttkB330 (rescues to 33% viable).

Xenogenetic Interactions
Statement
Reference
Complementation and Rescue Data
Partially rescued by
Comments

Scer\GAL4sli.PS-mediated expression of ttkp69.Scer\UAS partially rescues the CNS phenotype.

Images (0)
Mutant
Wild-type
Stocks (0)
Notes on Origin
Discoverer
External Crossreferences and Linkouts ( 0 )
Synonyms and Secondary IDs (1)
Reported As
Symbol Synonym
Name Synonyms
Secondary FlyBase IDs
    References (6)