FlyBase Allele Report: Dmel\Delta[B2]

General Information

Symbol

Dmel\Delta^B2

Species

D. melanogaster

Name

FlyBase ID

FBal0059141

Feature type

allele

Associated gene

Dmel\Delta

Associated Insertion(s)

Carried in Construct

Also Known As

Dl^B2

Key Links

Allele class

amorphic allele - genetic evidence

Mutagen

ethyl methanesulfonate

Nature of the Allele

Allele class

amorphic allele - genetic evidence

(Micchelli et al., 1997)

Mutagen

ethyl methanesulfonate

(Hukriede and Fleming, 1997)

Progenitor genotype

Cytology

Description

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

visible | adult stage

(Smylla et al., 2016)

visible | dominant

(Nagel et al., 2016)

Phenotype Manifest In

embryonic hindgut

(Iwaki and Lengyel, 2002)

fusion competent cell & visceral mesoderm

(Stute et al., 2004)

muscle founder cell & visceral mesoderm

(Stute et al., 2004)

wing

(Hukriede and Fleming, 1997)

wing vein

(Smylla et al., 2016)

wing vein | adult stage

(Nagel et al., 2016)

Detailed Description

Statement

Reference

Heterozygous Dl^B2 mutants display thickened veins and deltas at the margin of adult wings.

(Nagel et al., 2016)

Dl^B2/+ adult flies display thickened veins ending in deltas.

(Smylla et al., 2016)

Dl^B2/+ flies have a wild-type number of scutellar macrochaetae.

(Wildonger and Mann, 2005)

Marker expression and morphology suggest that numbers muscle founder cells are increased at the expense of fusion competent myoblasts in the visceral mesoderm of stage 11 Dl^B2 mutant embryos.

(Stute et al., 2004)

Mutant embryos are extremely deformed are do not always have a recognisable hindgut.

(Iwaki and Lengyel, 2002)

Heterozygotes with Ser^Bd-3 are viable and exhibit a severe wing phenotype.

(Hukriede and Fleming, 1997)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Enhanced by

Statement

Reference

Delta^B2 has visible | dominant phenotype, enhanceable by CycG^HR7/CycG^HR7

(Nagel et al., 2016)

Suppressed by

Statement

Reference

Delta^B2 has visible | adult stage phenotype, suppressible by H^attP/H[+]

(Smylla et al., 2016)

Delta^B2 has visible | adult stage phenotype, suppressible by H[+]/H^ΔM3

(Smylla et al., 2016)

Delta^B2 has visible | adult stage phenotype, suppressible by H^ΔM1-2/H[+]

(Smylla et al., 2016)

Delta^B2 has visible | adult stage phenotype, suppressible by H[+]/H^Cfs

(Smylla et al., 2016)

NOT suppressed by

Statement

Reference

Delta^B2 has visible | adult stage phenotype, non-suppressible by H^cwt/H[+]

(Smylla et al., 2016)

Delta^B2 has visible | adult stage phenotype, non-suppressible by H^ΔM1/H[+]

(Smylla et al., 2016)

Delta^B2 has visible | adult stage phenotype, non-suppressible by H^ΔM2/H[+]

(Smylla et al., 2016)

Enhancer of

Statement

Reference

Dl[+]/Delta^B2 is an enhancer of visible phenotype of Scer\GAL4^lz-gal4, sens^UAS.cNa

(Pepple et al., 2007)

Delta^B2 is an enhancer of visible phenotype of Myt1^GMR.PP

(Price et al., 2002)

Phenotype Manifest In

Enhanced by

Statement

Reference

Delta^B2 has wing vein | adult stage phenotype, enhanceable by CycG^HR7/CycG^HR7

(Nagel et al., 2016)

Suppressed by

Statement

Reference

Delta^B2 has wing vein phenotype, suppressible by H^attP/H[+]

(Smylla et al., 2016)

Delta^B2 has wing vein phenotype, suppressible by H[+]/H^ΔM3

(Smylla et al., 2016)

Delta^B2 has wing vein phenotype, suppressible by H^ΔM1-2/H[+]

(Smylla et al., 2016)

Delta^B2 has wing vein phenotype, suppressible by H[+]/H^Cfs

(Smylla et al., 2016)

NOT suppressed by

Statement

Reference

Delta^B2 has wing vein phenotype, non-suppressible by H^cwt/H[+]

(Smylla et al., 2016)

Delta^B2 has wing vein phenotype, non-suppressible by H^ΔM1/H[+]

(Smylla et al., 2016)

Delta^B2 has wing vein phenotype, non-suppressible by H^ΔM2/H[+]

(Smylla et al., 2016)

Enhancer of

Statement

Reference

Delta^B2 is an enhancer of eye phenotype of Myt1^GMR.PP

(Price et al., 2002)

Additional Comments

Genetic Interactions

Statement

Reference

The vein thickening phenotype of Dl^B2 heterozygotes is enhanced by combination with CycG^HR7. The severity of the phenotype differs with gender (more severe in males) and vein position (L2 and the junction between L4/L5 are particularly sensitive).

(Nagel et al., 2016)

The vein thickening and vein deltas characteristic for H^attP/+ adults is partially suppressible by combination with a single copy of H^attP and to a lesser extent also by heterozygosity of H^ΔM3, H^ΔM1-2 or H^Cfs but no significant rescue is observed upon combination with one copy of H^cwt, H^ΔM1 or H^ΔM2.

(Smylla et al., 2016)

Dl^B2/+ cannot restore the formation of interommatidial bristles in Df(1)sc10-1/Y flies.

Expression of sens^Scer\UAS.cNa under the control of Scer\GAL4^lz-gal4 can restore the formation of interommatidial bristles in Df(1)sc10-1/Y flies. If the flies also carry Dl^B2/+, the number of bristles formed is further increased and there is a further loss of the normal ommatidial surface architecture.

(Pepple et al., 2007)

Dl^B2/+; nvy^PDFKG1/+ flies have a wild-type number of scutellar macrochaetae.

(Wildonger and Mann, 2005)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (2)