FB2026_02 , released June 18, 2026
FB2026_02 , released June 18, 2026
Allele: Dmel\stil5
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General Information
Symbol
Dmel\stil5
Species
D. melanogaster
Name
FlyBase ID
FBal0059926
Feature type
allele
Associated gene
Dmel\stil
Associated Insertion(s)
Carried in Construct
Key Links
Allele class

hypomorphic allele - genetic evidence

Mutagen
Nature of the Allele
Allele class

hypomorphic allele - genetic evidence

(Pennetta and Pauli, 1997)
Mutagen
diepoxybutane
(Pennetta and Pauli, 1997)
Progenitor genotype
Cytology
Description

65bp deletion and insertion of 5bp, resulting in a frame shift and truncation of the protein after amino acid 97 and the addition of 20 unrelated residues.

(Sahut-Barnola and Pauli, 1999)
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      The male germline appears completely normal in stil5 adults.

      (Sahut-Barnola and Pauli, 1999)

      Most ovaries of 5 day old homozygous females contain a few germ cells, while the number of ovaries completely lacking germ cells increases with age. Hemizygous stil4/Df(2R)vg135 females have a stronger phenotype, with a greater proportion of ovaries completely lacking germ cells. stil5/stil6 ovaries show sexual transformation, containing some male-like germ cells which resemble spermatocytes. Nurse cells and male-like cells are seen in the same ovary, suggesting that they are mosaic in terms of germ cell sexual identity. The dominant ovoD2 phenotype is not significantly enhanced by one copy of stil5.

      (Pennetta and Pauli, 1997)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      Comments
      Comments

      Isolated in a screen for lethal or sterile mutations uncovered by Df(2R)vg135.

      (Pennetta and Pauli, 1997)
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (1)
      Reported As
      Symbol Synonym
      stil5
      Name Synonyms
      Secondary FlyBase IDs
        References (2)