FB2026_02 , released June 18, 2026
FB2026_02 , released June 18, 2026
Allele: Dmel\stil4
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General Information
Symbol
Dmel\stil4
Species
D. melanogaster
Name
FlyBase ID
FBal0059927
Feature type
allele
Associated gene
Dmel\stil
Associated Insertion(s)
Carried in Construct
Key Links
Genomic Maps

Allele class

hypomorphic allele - genetic evidence

Mutagen
Nature of the Allele
Allele class

hypomorphic allele - genetic evidence

(Pennetta and Pauli, 1997)
Mutagen
ethyl methanesulfonate
(Pennetta and Pauli, 1997)
Progenitor genotype
Cytology
Description

Amino acid replacement: P19S.

(Sahut-Barnola and Pauli, 1999)
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
point_mutation
2R:12,570,503..12,570,503 [+]
Nucleotide change:

C12570503T

Amino acid change:

P19S | stil-PA

Reported amino acid change:

P19S|FBrf0108423

Comment:

site of nucleic acid difference inferred by FlyBase curator based on reported amino acid change

(Sahut-Barnola and Pauli, 1999)
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Most ovaries of 5 day old homozygous females contain a few germ cells, while the number of ovaries completely lacking germ cells increases with age. Hemizygous stil4/Df(2R)vg135 females have a stronger phenotype, with a greater proportion of ovaries completely lacking germ cells. stil1/stil4 ovaries have relatively normal egg chambers, although the oocyte is often in an abnormal position. The dominant ovoD2 phenotype is not significantly enhanced by one copy of stil4.

      (Pennetta and Pauli, 1997)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (1)
      Notes on Origin
      Discoverer
      Comments
      Comments

      Isolated in a screen for lethal or sterile mutations uncovered by Df(2R)vg135.

      (Pennetta and Pauli, 1997)
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (1)
      Reported As
      Symbol Synonym
      stil4
      Name Synonyms
      Secondary FlyBase IDs
        References (2)