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General Information
Symbol
Dmel\mof1
Species
D. melanogaster
Name
FlyBase ID
FBal0059998
Feature type
allele
Associated gene
Associated Insertion(s)
Carried in Construct
Key Links
Allele class
Nature of the Allele
Allele class
Mutations Mapped to the Genome
 
Type
Location
Additional Notes
References
Nucleotide change:

G5874681A

Amino acid change:

G691E | mof-PA

Reported amino acid change:

G691E

Comment:

Site of nucleotide substitution in mutant inferred by FlyBase based on reported amino acid change.

Associated Sequence Data
DNA sequence
Protein sequence
 
 
Progenitor genotype
Cytology
Nature of the lesion
Statement
Reference

Amino acid replacement: G691E.

Expression Data
Reporter Expression
Additional Information
Statement
Reference
 
Marker for
Reflects expression of
Reporter construct used in assay
Human Disease Associations
Disease Ontology (DO) Annotations
Models Based on Experimental Evidence ( 0 )
Disease
Evidence
References
Modifiers Based on Experimental Evidence ( 0 )
Disease
Interaction
References
Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
 
Disease-implicated variant(s)
 
Phenotypic Data
Phenotypic Class
Phenotype Manifest In
Detailed Description
Statement
Reference

mof1 eye imaginal discs of third instar larvae show a substantial level of basal apoptotic cells, above that seen in controls. This high basal level is only slightly increased in mutants following exposure to 25 Gy ionizing radiation, to levels similar to that in controls exposed to the same.

In contrast to controls, mof1 wing imaginal discs do not show a significant decrease in mitotic indices following exposure to 25 Gy ionizing radiation.

Young homozygous mof1 females generate normal numbers of eggs and fecundity does not drop significantly between 3 and 13 days post-eclosion.

Males derived from a cross of homozygous females to wild-type males show appreciable survival to larval stages (day 5) in the presence of infection with the "male-killing" bacterium S.poulsonii. Infected male embryos derived from a cross of heterozygous females to wild-type males show no survival to day 5.

Males can develop to the third larval instar or the prepupal stage but fail to metamorphose and to hatch. msl-2Hsp83.PK females exhibit a very long developmental delay and a significant loss of viability, normal development is restored by removing one functional copy of mof.

External Data
Interactions
Show genetic interaction network for Enhancers & Suppressors
Phenotypic Class
Other
Statement
Reference
Phenotype Manifest In
NOT Enhancer of
Statement
Reference

mof[+]/mof1 is a non-enhancer of adult thorax | pharate adult stage phenotype of chm14

Suppressor of
NOT Suppressor of
Statement
Reference

mof[+]/mof1 is a non-suppressor of adult thorax | pharate adult stage phenotype of chm14

Additional Comments
Genetic Interactions
Statement
Reference

The X polytene chromosome condensation defects observed in larval salivary glands of Top2suo3/Top2suo1 males can be rescued by combination with mof1 in hemizygote state: the X polytene chromosome of mof1/Y;Top2suo3/Top2suo1 double mutants shows normal condensation as well as banding pattern.

Doubly homozygous mof1; nosBN females are nearly as prolific as nosBN controls 3-8 days post-eclosion. However, their fecundity drops dramatically 9-13 days post-eclosion.

Xenogenetic Interactions
Statement
Reference
Complementation and Rescue Data
Not rescued by
Comments

mof1 rescues the male-specific lethality of mof1.

Expression of mofHsp83.T:Ivir\HA1,T:Scer\GAL4-DBD fails to rescue males from the lethal effects of mof1.

Images (0)
Mutant
Wild-type
Stocks (0)
Notes on Origin
Discoverer
Comments
Comments

Immunofluorescence determines that msl-1 and msl-2 binding to the X chromosome is reduced, binding of mle is substantially reduced. X-specific isoform of His4 is absent.

External Crossreferences and Linkouts ( 0 )
Synonyms and Secondary IDs (2)
References (23)