mof1 eye imaginal discs of third instar larvae show a substantial level of basal apoptotic cells, above that seen in controls. This high basal level is only slightly increased in mutants following exposure to 25 Gy ionizing radiation, to levels similar to that in controls exposed to the same.
In contrast to controls, mof1 wing imaginal discs do not show a significant decrease in mitotic indices following exposure to 25 Gy ionizing radiation.
Young homozygous mof1 females generate normal numbers of eggs and fecundity does not drop significantly between 3 and 13 days post-eclosion.
Males derived from a cross of homozygous females to wild-type males show appreciable survival to larval stages (day 5) in the presence of infection with the "male-killing" bacterium S.poulsonii. Infected male embryos derived from a cross of heterozygous females to wild-type males show no survival to day 5.
Males can develop to the third larval instar or the prepupal stage but fail to metamorphose and to hatch. msl-2Hsp83.PK females exhibit a very long developmental delay and a significant loss of viability, normal development is restored by removing one functional copy of mof.