FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\grauQF31
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General Information
Symbol
Dmel\grauQF31
Species
D. melanogaster
Name
FlyBase ID
FBal0060397
Feature type
allele
Associated gene
Dmel\grau
Associated Insertion(s)
Carried in Construct
Key Links
Genomic Maps

Allele class
Mutagen
Nature of the Allele
Allele class
Mutagen
ethyl methanesulfonate
(Page and Orr-Weaver, 1996, Schupbach and Wieschaus, 1989)
Progenitor genotype
Cytology
Description

74bp deletion between bases 823 and 898. This causes a frameshift and introduces a stop codon within the first zinc finger motif.

(Chen et al., 2000)
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
deletion
2R:21,010,920..21,010,993 [-]
Comment:

74bp deletion which causes a frameshift and introduces a stop codon within the first zinc finger motif. The position of the mutation on the reference sequence was inferred by a FlyBase curator.

(Chen et al., 2000)
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      A small percentage of embryos laid by grauQF31/Df(2R)Pu-D17 females develop into adult flies.

      (Chen et al., 2000)

      Only 2.6-3.0% of embryos derived from homozygous females progress through meiosis and develop.

      (Harms et al., 2000)

      Transmission rate of Dp(1;f)J21A through females to progeny is 28%, grau mutation has no effect on transmission. Mutation has no effect on Dp(1;f)J21A transmission in males.

      (Cook et al., 1997)

      Females lay eggs that arrest in meiosis II, the earliest defect is in anaphase I. Premature sister chromatid separation does not rescue the meiotic defects, as shown in mei-S3321 double mutants. Male meiosis and mitosis are normal.

      (Page and Orr-Weaver, 1996)

      Eggs derived from homozygous females initiate development and cytoplasmic clearing occurs in a narrow zone around the egg periphery (in wild-type embryos this process is coupled to the arrival of the nuclei at the periphery). The eggs do not seem to develop beyond this stage; pole cells are not formed and cellularisation does not occur. However, about two hours after cytoplasmic clearing, the egg periphery starts to show local contractions, in what might be an attempt at gastrulation. These contractions eventually lead to eggs which typically have one or two condensed yolk balls surrounded by more transparent cytoplasm.

      (Schupbach and Wieschaus, 1989)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Enhanced by
      Statement
      Reference

      Df(2R)Pu-D17/grauQF31 has lethal | maternal effect phenotype, enhanceable by cortQW55/cort[+]

      (Chen et al., 2000)

      Df(2R)Pu-D17/grauQF31 has lethal | maternal effect phenotype, enhanceable by cortRH65/cort[+]

      (Chen et al., 2000)
      Suppressed by
      Statement
      Reference

      grauQF31 has abnormal meiotic cell cycle | recessive phenotype, suppressible by cort+t2.7

      (Harms et al., 2000)

      grauQF31 has lethal | recessive | maternal effect | embryonic stage phenotype, suppressible by cort+t2.7

      (Harms et al., 2000)
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference

      The small percentage of developing embryos laid by grauQF31/Df(2R)Pu-D17 females is abolished if the females are also heterozygous for cortQW55 or cortRH65.

      (Chen et al., 2000)

      88.4-94.8% of embryos derived from grauQF31/grauQF31 ; cort+t2.7 females progress through meiosis and develop.

      (Harms et al., 2000)
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (1)
      Reported As
      Symbol Synonym
      grauQF31
      Name Synonyms
      Secondary FlyBase IDs
        References (6)