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General Information
Symbol
Btau\MAPTisl.H.Tag:MYC
Species
B. taurus
Name
FlyBase ID
FBal0060490
Feature type
allele
Associated gene
Associated Insertion(s)
Carried in Construct
Also Known As
islH-tau-myc, islet-tau-myc, isl-H-tau-myc
Allele class
Nature of the Allele
Allele class
Mutations Mapped to the Genome
 
Type
Location
Additional Notes
References
Associated Sequence Data
DNA sequence
Protein sequence
 
 
Progenitor genotype
Carried in construct
Cytology
Nature of the lesion
Statement
Reference

A 7kb genomic fragment located 6 to 13kb upstream of the tup putative transcriptional start site is fused upstream of a minimal Hsp70 promoter driving expression of bovine Btau\MAPT tagged with six copies of Tag:MYC.

Allele components
Product class / Tool use(s)
Encoded product / tool
Associated Sequence Features
Expression Data
Reporter Expression
distribution deduced from reporter
Stage
Tissue/Position (including subcellular localization)
Reference
Additional Information
Statement
Reference

Btau\MAPTisl.H.T:Hsap\MYC drives expression in a subset of ventral motor neurons which exit the ventral nerve cord via the ISNb nerve branch. There is co-expression with Oli protein.

Reporter construct studies indicate that Lim3 is co-expressed with tup in a subset of motor neurons. For the intersegmental nerve, all the ISNb-specific motor neurons express both Lim3 and tup, while those projecting in ISNd only express tup. Lim3 is not co-expressed with tup or ap in interneurons. Motor neurons co-expressing tup and Lim3 include motor neurons RP1, RP3, RP4, RP5, the contralateral V motor neuron which innervates muscle 12, and MN28 and MN14/30 which innervate muscles 28 and 14 plus 30, respectively. The tup-expressing motor neurons projecting in ISNd innervate muscles 15-17.

Reporter expression is not detected in neuroblasts but in postmitotic neurons, in a subset of motor neurons and interneurons. The subset of motor neurons expressing the reporter innervate muscles located ventrally in the body wall, and include RP1, RP3 and RP4. Reporter expression is detected in 3 morphologically different classes of interneurons. Double staining for ap and tup reporters reveal that they are expressed in nonoverlapping subsets of neurons that project axons along different pathways.

 
Marker for
Reporter construct used in assay
Human Disease Associations
Disease Ontology (DO) Annotations
Models Based on Experimental Evidence ( 0 )
Disease
Evidence
References
Modifiers Based on Experimental Evidence ( 0 )
Disease
Interaction
References
Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
 
Disease-implicated variant(s)
 
Phenotypic Data
Phenotypic Class
Phenotype Manifest In
Detailed Description
Statement
Reference
External Data
Interactions
Show genetic interaction network for Enhancers & Suppressors
Phenotypic Class
Phenotype Manifest In
Additional Comments
Genetic Interactions
Statement
Reference
Xenogenetic Interactions
Statement
Reference
Complementation and Rescue Data
Comments
Images (0)
Mutant
Wild-type
Stocks (0)
Notes on Origin
Discoverer
External Crossreferences and Linkouts ( 0 )
Synonyms and Secondary IDs (4)
Reported As
Symbol Synonym
Btau\MAPTisl.H.T:Hsap\MYC
Btau\MAPTisl.H.Tag:MYC
btauisl.H.T:Myc
Name Synonyms
Secondary FlyBase IDs
    References (14)