FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\mxc16a-1
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General Information
Symbol
Dmel\mxc16a-1
Species
D. melanogaster
Name
FlyBase ID
FBal0061018
Feature type
allele
Associated gene
Dmel\mxc
Associated Insertion(s)
Carried in Construct
Key Links
Genomic Maps

Allele class
Mutagen
Nature of the Allele
Allele class
Mutagen
gamma ray
(Docquier et al., 1996)
Progenitor genotype
Cytology
Description

In addition to the C-terminal truncation previously reported (FBrf0213662), the mxc coding sequence contains amino acid substitutions A662V and T1321A compared to the reference genome sequence. It is not known which of the lesions is responsible for the malignant tumor phenotype seen in this allele.

(Kurihara et al., 2020)

Deletion of 4bp (TTCG) at position F1823, resulting in a frameshift

(White et al., 2011)
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
deletion
X:9,237,302..9,237,305 [-]
Comment:

Deletion of 4bp (TTCG) at position F1824, resulting in a frameshift.

(White et al., 2011)
point_mutation
X:9,238,950..9,238,950 [-]
Nucleotide change:

T9238950A

Amino acid change:

S1321T | mxc-PA; S1321T | mxc-PB

Reported amino acid change:

S1321T

Comment:

In addition to the 4bp deletion, two subsititution mutations are present in mxc16a-1. Site and nature of nucleotide substitution in mutant inferred by FlyBase curator based on reported amino acid change.

(Kurihara et al., 2020)
point_mutation
X:9,240,926..9,240,926 [-]
Nucleotide change:

C9240926T

Amino acid change:

A662V | mxc-PA; A662V | mxc-PB

Reported amino acid change:

A662V

Comment:

In addition to the 4bp deletion, two subsititution mutations are present in mxc16a-1. Site and nature of nucleotide substitution in mutant inferred by FlyBase curator based on reported amino acid change.

(Kurihara et al., 2020)
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 1 )
      Disease
      Evidence
      References
      model of  hematologic cancer
      CEA
      (Remillieux-Leschelle et al., 2002)
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Hemizygous larvae have small imaginal discs and overgrown lymph glands. The concentration of circulating hemocytes in third instar larvae is significantly increased compared to controls and the fraction of circulating hemocytes that are undergoing cell division is also increased. The number of crystal cells per larva is significantly reduced compared to controls. The larvae show a significant increase in a blood cell type ("podocytes") with large pseudopod-like extensions compared to controls. These cells appear pear-shaped or spindle-shaped. Mutant larvae contain an increased fraction of lamellocytes (1.7%) compared to controls (0.2%). 80% of hemizygous lymph glands transplanted into wild-type females show an increase in size 5 days after transplantation, in contrast to wild-type lymph gland transplants, which do not show growth.

      (Remillieux-Leschelle et al., 2002)

      Hemizygous larvae are smaller than normal and develop slowly. The larvae remain at the wandering stage for up to 7 days without forming pupae. The imaginal discs and brain are reduced in size. The eye-antennal, leg and wing discs appear more deformed than the haltere or genital discs. The prothoracic leg discs of most larvae develop as a fused mass of tissue at 25oC. Mitotic figures and metaphase chromosome morphology of larval brain squashes do not show striking anomalies. Cell death occurs throughout hemizygous wing imaginal discs. Almost all third instar larvae have melanotic pseudotumours.

      (Saget et al., 1998)

      Homozygotes die as late larvae or early pupae. mxcG9/mxc16a-1 females have fewer egg chambers than wild-type flies, but are fully fertile and fecund. mxcM1/mxc16a-1 and mxcG46/mxc16a-1 females do not lay eggs. Some egg chambers contain the normal number of nurse cells, but oogenesis appears arrested before stage 7-8. Egg chambers degenerate in older flies.

      (Docquier et al., 1996)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (1)
      Notes on Origin
      Discoverer

      C. Wieland.

      (Docquier et al., 1996)
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (1)
      Reported As
      Symbol Synonym
      mxc16a-1
      (Sang et al., 2022, Kurihara et al., 2020, White et al., 2011, Randsholt, 2009.1.22)
      Name Synonyms
      Secondary FlyBase IDs
        References (8)