FlyBase Allele Report: Dmel\abs[II-F1]

General Information

Symbol

Dmel\abs^II-F1

Species

D. melanogaster

Name

FlyBase ID

FBal0061527

Feature type

allele

Associated gene

Dmel\abs

Associated Insertion(s)

Carried in Construct

Also Known As

abs^IIF1

Key Links

Genomic Maps

JBrowse

Allele class

loss of function allele

Mutagen

ethyl methanesulfonate

Nature of the Allele

Allele class

loss of function allele

(Schmucker et al., 2000)

Mutagen

ethyl methanesulfonate

(Schmucker et al., 1997)

Progenitor genotype

Cytology

Description

Amino acid replacement: G517S.

(Schmucker et al., 2000)

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

point_mutation

3R:4,234,677..4,234,677 [+]

Nucleotide change:

G4234677A

Amino acid change:

G517S | abs-PA

Reported amino acid change:

G517S

Comment:

Site of nucleic acid difference inferred by FlyBase based on reported amino acid change.

(Schmucker et al., 2000)

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

Phenotype Manifest In

Bolwig nerve (with abs^45LR7)

(Schmucker et al., 2000)

central nervous system

(Schmucker et al., 2000)

larval longitudinal connective

(Schmucker et al., 2000)

Detailed Description

Statement

Reference

In homozygous abs^II-F1 mutants aberrant central nervous system (CNS) fibres can be observed in the intercommissural space and the connectives are weakened and occasionally absent. Overall the CNS appears less compact than in wild-type. abs^II-F1/abs^45LR7 mutants the Bolwig's nerve (BN) appears thicker and morphologically abnormal and defasciculates into separate branches.

(Schmucker et al., 2000)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Phenotype Manifest In

Additional Comments

Genetic Interactions

Statement

Reference

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Rescued by

abs^II-F1 is rescued by abs^+t15.6

(Schmucker et al., 2000)

abs^II-F1 is rescued by abs^+t10.8

(Schmucker et al., 2000)

Partially rescued by

abs^II-F1 is partially rescued by abs^+t5.8

(Irion and Leptin, 1999)

Comments

Lethality is suppressed by the addition of abs^+t5.8.

(Irion and Leptin, 1999)

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

Comments

Phenotypic analysis provides an allelic series: abs^E2 << abs⁰⁴⁵⁰⁵ = abs⁰⁰⁶²⁰ < abs^II-F1 = abs^45LR7.

(Schmucker et al., 2000)

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (3)

Reported As

Symbol Synonym

abs^II-F1

abs^IIF1

(Schmucker et al., 2000, Irion and Leptin, 1999)

abs^IIF

(Irion and Leptin, 1999)

Name Synonyms

Secondary FlyBase IDs

References (3)

Report Sections

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