FB2026_02 , released June 18, 2026
Allele: Dmel\Gs1fsP52
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General Information
Symbol
Dmel\Gs1fsP52
Species
D. melanogaster
Name
FlyBase ID
FBal0061859
Feature type
allele
Associated gene
Dmel\Gs1
Associated Insertion(s)
P{hsneo}Gs1fsP52
Carried in Construct
Key Links
Allele class

hypomorphic allele - genetic evidence

Mutagen
Nature of the Allele
Allele class

hypomorphic allele - genetic evidence

(Frenz and Glover, 1996)
Mutagen
P-element activity
(Frenz and Glover, 1996)
Progenitor genotype
Associated Insertion(s)
P{hsneo}Gs1fsP52
Cytology
Description

P{hsneo} insertion within the 5' end of the coding region of Gs1.

(Frenz and Glover, 1996)
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Embryos have an increased number of polyploid, pseudo-yolk nuclei by stage 10 and as development proceeds the number increases dramatically. These nuclei are present throughout the interior of the embryo, not restricted to a small region along the anterior-posterior axis as in wild type. Nuclei fall from the cortex of embryos leaving behind microtubular asters and centrosomes. Mitotic progression is abnormal in syncytial embryos. Mutation confers hypersensitivity to paraquat and X-radiation.

      (Frenz and Glover, 1996)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Rescued by

      Gs1fsP52 is rescued by Gs1+t4.8

      (Frenz and Glover, 1996)
      Not rescued by

      Gs1fsP52 is not rescued by Gs1P52-m

      (Frenz and Glover, 1996)
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (1)
      Notes on Origin
      Discoverer
      Comments
      Comments

      Phenotypic reversion associated with mobilisation of the P{hsneo} demonstrates the insertion is responsible for the mutant phenotype.

      (Frenz and Glover, 1996)
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (2)
      Reported As
      Symbol Synonym
      Gs1fsP52
      fs(2)P52
      (Frenz and Glover, 1996)
      Name Synonyms
      Secondary FlyBase IDs
        References (1)