FlyBase Allele Report: Dmel\Dsor1[Su4]

General Information

Symbol

Dmel\Dsor1^Su4

Species

D. melanogaster

Name

FlyBase ID

FBal0061972

Feature type

allele

Associated gene

Dmel\Dsor1

Associated Insertion(s)

Carried in Construct

Key Links

Genomic Maps

JBrowse

Allele class

Mutagen

Nature of the Allele

Allele class

Mutagen

Progenitor genotype

Cytology

Description

Amino acid replacement: G144D.

(Lim et al., 1997)

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

point_mutation

X:9,248,871..9,248,871 [+]

Nucleotide change:

G9248871A

Amino acid change:

G147D | Dsor1-PA; G144D | Dsor1-PB

Reported amino acid change:

G144D

Comment:

Reported as G144D in FBrf93573. Maps to G147D in the CDS encoded by the reference sequence. The difference is due to the use of an upstream splice acceptor in an upstream intron . The annotated version is supported by full length cDNA LD41207 (GB:AY058692). The site of the nucleotide substitution in the mutant was inferred by FlyBase based on the reported amino acid change.

(Lim et al., 1997)

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

Phenotype Manifest In

ommatidium

(Lim et al., 1997)

photoreceptor cell R7

(Lim et al., 1997)

Detailed Description

Statement

Reference

The number of R7-like cells per ommatidium is slightly increased in homozygotes compared to wild-type flies.

(Lim et al., 1997)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Phenotype Manifest In

Enhancer of

Statement

Reference

Dsor1^Su4 is an enhancer of eye phenotype of Raf::tor^12D.sev

(Lim et al., 1997)

Suppressor of

Statement

Reference

Dsor1^Su4 is a suppressor of head phenotype of Egfr^f7

(Lim et al., 1997)

Dsor1^Su4 is a suppressor of phenotype of Raf¹

(Lim et al., 1997)

Dsor1^Su4 is a suppressor of phenotype of sev⁶

(Lim et al., 1997)

Dsor1^Su4 is a suppressor of phenotype of tor⁴

(Lim et al., 1997)

Other

Statement

Reference

Dsor1^Su4, Sos^JC2 has ommatidium phenotype

(Lim et al., 1997)

Dsor1^Su4, Sos^JC2 has photoreceptor cell R7 phenotype

(Lim et al., 1997)

Additional Comments

Genetic Interactions

Statement

Reference

Completely suppresses the eye phenotype of phl¹ hemizygotes. Sos^JC2 heterozygotes also hemizygous for Dsor1^Su4 have 3.01 +/- 0.72 R7-like cells per ommatidium. Partly suppresses the sev⁶ phenotype; flies hemizygous for sev⁶ and Dsor1^Su4 have an R7 photoreceptor cell in 8.9% of ommatidia. Partly suppresses the maternal tor⁴ phenotype; 99.7% of embryos derived from tor⁴ Dsor1^Su4 females have an A8 segment. Enhances the phl::tor^12D.sev rough eye phenotype. Partly suppresses the Egfr^f7 phenotype.

(Lim et al., 1997)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (1)

Reported As

Symbol Synonym

Dsor1^Su4

Name Synonyms

Secondary FlyBase IDs

References (1)

Report Sections

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