FB2026_02 , released June 18, 2026
Allele: Dmel\piounspecified
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General Information
Symbol
Dmel\piounspecified
Species
D. melanogaster
Name
FlyBase ID
FBal0062503
Feature type
allele
Associated gene
Dmel\pio
Associated Insertion(s)
Carried in Construct
Key Links
Allele class
Mutagen
    Nature of the Allele
    Allele class
    Mutagen
    Progenitor genotype
    Cytology
    Description

    FlyBase curator comment: this entry is used to capture phenotypic information when the particular allele (or allele combination) used by the author could not be determined but the context of the experiment suggests that the phenotype being described is some kind of loss of function.

    (FlyBase Curators, 2025-)
    Mutations Mapped to the Genome
    Curation Data
    Type
    Location
    Additional Notes
    References
    Variant Molecular Consequences
    Associated Sequence Data
    DDBJ / EMBL / GenBank
    DNA sequence
    Protein sequence
     
    UniProtKB/Swiss-Prot
      UniProtKB/TrEMBL
        Expression Data
        Reporter Expression
        Additional Information
        Statement
        Reference
         
        Marker for
        Reflects expression of
        Reporter construct used in assay
        Human Disease Associations
        Disease Ontology (DO) Annotations
        Models Based on Experimental Evidence ( 0 )
        Disease
        Evidence
        References
        Modifiers Based on Experimental Evidence ( 0 )
        Disease
        Interaction
        References
        Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
         
        Disease-implicated variant(s)
         
        Phenotypic Data
        Phenotypic Class
        Phenotype Manifest In
        Detailed Description
        Statement
        Reference

        Many flies that contain mutant clones have pits or protrusions on the thorax in the vicinity of the flight muscle attachments.

        When mutant clones are induced in the wing, a wing blister appears within a few minutes of eclosion of the adult flies from the pupal case.

        Mutant clones in the pupal wing completely lack the transalar microtubule arrays that are normally seen spanning the wing cells at this stage. This results in an expansion of the mutant cells and a contraction of the wild-type cells in the opposing epithelial layer. The two epithelial sheets of the wing remain associated.

        Homozygous embryos complete development but the tracheae appear twisted and broken and the cuticle detaches from the epidermis.

        (Bokel et al., 2005)

        Homozygous clones in the wing produce large blisters that lack sharp boundaries. Wings are sometimes rumpled. Homozygous embryos show excessive contractions of the segmental muscles just before hatching. The posterior segments are compacted and the muscles appear shorter than normal.

        (Prout et al., 1997)
        External Data
        Interactions
        Show genetic interaction network for Enhancers & Suppressors
        Phenotypic Class
        Enhancer of
        Statement
        Reference

        pio[+]/piounspecified is an enhancer of visible | recessive phenotype of mys8

        (Prout et al., 1997)
        Phenotype Manifest In
        NOT suppressed by
        Statement
        Reference

        piounspecified has cytoplasmic microtubule & wing | somatic clone phenotype, non-suppressible by pio::torUAS.cBa/Scer\GAL4unspecified

        (Bokel et al., 2005)
        Enhancer of
        Statement
        Reference

        pio[+]/piounspecified is an enhancer of wing phenotype of mys8

        (Prout et al., 1997)
        Additional Comments
        Genetic Interactions
        Statement
        Reference

        The loss of the transalar microtubule arrays seen in piounspecified clones in the pupal wing is not rescued by expression of pio::torScer\UAS.cBa in the pupal wings under the control of Scer\GAL4unspecified.

        (Bokel et al., 2005)

        Shows a weak genetic interaction with mys8; the frequency of held-out wings but not the frequency of blisters in mys8 single hemizygotes is increased if they are also heterozygous for piounspecified. Shows no interaction with mysb9.

        (Prout et al., 1997)
        Xenogenetic Interactions
        Statement
        Reference
        Complementation and Rescue Data
        Rescued by

        piounspecified is rescued by pio+t22

        (Bokel et al., 2005)
        Comments
        Images (0)
        Mutant
        Wild-type
        Stocks (0)
        Notes on Origin
        Discoverer
        External Crossreferences and Linkouts ( 0 )
        Synonyms and Secondary IDs (2)
        Reported As
        Symbol Synonym
        piounspecified
        unspecified
        (Prout et al., 1997)
        Name Synonyms
        Secondary FlyBase IDs
          References (3)