FB2026_02 , released June 18, 2026
Allele: Dmel\inaDT2
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General Information
Symbol
Dmel\inaDT2
Species
D. melanogaster
Name
FlyBase ID
FBal0062793
Feature type
allele
Associated gene
Dmel\inaD
Associated Insertion(s)
Carried in Construct
Also Known As
inaD2
Key Links
Genomic Maps

Allele class
Mutagen
Nature of the Allele
Allele class
Mutagen
ethyl methanesulfonate
(Tsunoda et al., 1997)
Progenitor genotype
Cytology
Description

Nucleotide substitution: A1814G. Amino acid replacement: G?E. In the fifth PDZ domain.

(Tsunoda et al., 1997)
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
point_mutation
2R:22,856,043..22,856,043 [-]
Nucleotide change:

G22856043A

Reported nucleotide change:

A1814G

Amino acid change:

G605E | inaD-PA; G617E | inaD-PB

Reported amino acid change:

G?E

Comment:

Site of nucleotide substitution in mutant inferred by FlyBase based on reported amino acid change.

(Tsunoda et al., 1997)
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      In response to single photons, photoreceptors of inaDT2 flies show normal quantum bump shape and amplitude, but a dramatically lengthened latency.

      (Mishra et al., 2007)

      Mutant flies are unable to discriminate between long and short light stimuli (in contrast to wild-type flies).

      (Cook et al., 2000)

      Mutants show severe quantum bump defects, with latency times over eight times larger than those of wild type.

      (Scott and Zuker, 1998)

      inaDT2 flies have an abnormal electroretinogram (ERG) phenotype, with severe defects in response to light. Loss of responsiveness to light increases with age.

      (Tsunoda et al., 1997)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Suppressor of
      Statement
      Reference

      inaDT2 is a suppressor of rhabdomere phenotype of rdgA1

      (Georgiev et al., 2005)
      Additional Comments
      Genetic Interactions
      Statement
      Reference

      The retinal degeneration phenotype of rdgA1 flies is suppressed by inaDT2.

      (Georgiev et al., 2005)
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (3)
      Reported As
      Symbol Synonym
      InaD2
      (Georgiev et al., 2005)
      inaD2
      (Mishra et al., 2007, Cook et al., 2000, Scott and Zuker, 1998, Tsunoda et al., 1997)
      inaDT2
      Name Synonyms
      Secondary FlyBase IDs
        References (5)