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General Information
Symbol
Dmel\egP289
Species
D. melanogaster
Name
FlyBase ID
FBal0062865
Feature type
allele
Associated gene
Associated Insertion(s)
Carried in Construct
Also Known As
Eg-lacZ, eg289
Key Links
Nature of the Allele
Mutations Mapped to the Genome
 
Type
Location
Additional Notes
References
Associated Sequence Data
DNA sequence
Protein sequence
 
 
Progenitor genotype
Cytology
Nature of the lesion
Statement
Reference

Insertion of a P{lArB} element approximately 200bp upstream of 5' exon A2.

Insertion components
P{lArB}egP289
Product class / Tool use(s)
Encoded product / tool
Expression Data
Reporter Expression
Additional Information
Statement
Reference
 
Marker for
Reflects expression of
Reporter construct used in assay
Human Disease Associations
Disease Ontology (DO) Annotations
Models Based on Experimental Evidence ( 0 )
Disease
Evidence
References
Modifiers Based on Experimental Evidence ( 0 )
Disease
Interaction
References
Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
 
Disease-implicated variant(s)
 
Phenotypic Data
Phenotypic Class
Phenotype Manifest In
Detailed Description
Statement
Reference

Many hemisegments show severe reduction in the number of serotonin neuron: mutants exhibit a single cell instead of the normal mitotic pair in thoracic and abdominal segments. nub and zfh2 staining reveals the more medial serotonin cell of the mitotic pair is lost: the EW1 neuron. 15% pupae survive to become viable adults, adults exhibit reduced number of serotonin neurons in the ventral cord. Both larvae and flies appear normal for phototaxis and geotaxis. The adults are much less active in locomotion. Flight is impossible due to the extended wings. Adults also have difficulty holding onto glass surfaces when climbing vertically or when rotated upside down, flies have no obvious morphological defects in the legs or tarsi.

Homozygotes have a 'wings held out' phenotype. Interneuronal projections derived from the NB 7-3 neuroblast show severe pathfinding defects, failing to cross the midline and showing variable orientations. The motorneuron derived from NB 7-3 appears to have a normal axonal projection. NB 7-3 clones contain more cells than normal in the thorax. Serotonergic cells are almost entirely lacking in the central nervous system of egP289 first instar larvae.

External Data
Interactions
Show genetic interaction network for Enhancers & Suppressors
Phenotypic Class
Phenotype Manifest In
Additional Comments
Genetic Interactions
Statement
Reference
Xenogenetic Interactions
Statement
Reference
Complementation and Rescue Data
Comments
Images (0)
Mutant
Wild-type
Stocks (0)
Notes on Origin
Discoverer
External Crossreferences and Linkouts ( 0 )
Synonyms and Secondary IDs (2)
Reported As
Symbol Synonym
Name Synonyms
Secondary FlyBase IDs
    References (3)