FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Gene: Dmel\eg
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General Information
Symbol
Dmel\eg
Species
D. melanogaster
Name
eagle
Annotation Symbol
CG7383
Feature Type
protein_coding_gene
FlyBase ID
FBgn0000560
Gene Model Status
Current
Stock Availability
33 publicly available
Gene Summary
eagle (eg) encodes a transcription factor of the nuclear hormone receptor subfamily O. Its roles include serotonergic differentiation (in combination with the product of hkb) and axonal pathfinding. [Date last reviewed: 2019-03-07] (FlyBase Gene Snapshot)
All Summaries
Also Known As

egon, egl, spy

Key Links
Genomic Location
Cytogenetic map
78F2-78F3
Sequence location
Recombination map
3-47
RefSeq locus
NT_037436 REGION:21808703..21817600
Sequence
Get Decorated FASTA
Genomic Maps
Other Genome Views
The following external sites may use different assemblies or annotations than FlyBase.
NCBI
UCSC
Ensembl
PopFly
Function
Gene Ontology (GO) Annotations (10 terms)
Molecular Function (5 terms)
Terms Based on Experimental Evidence (0 terms)
Terms Based on Predictions or Assertions (5 terms)
CV Term
Evidence
References
enables DNA-binding transcription factor activity
inferred from electronic annotation with InterPro:IPR001628
(InterPro Project Members, 2004-)
enables estrogen response element binding
inferred from biological aspect of ancestor with PANTHER:PTN001182563
(GO Reference Genome Project, 2011-)
enables nuclear receptor activity
inferred from biological aspect of ancestor with PANTHER:PTN002377694
(GO Reference Genome Project, 2011-)
enables sequence-specific DNA binding
inferred from electronic annotation with InterPro:IPR001628
(InterPro Project Members, 2004-)
enables zinc ion binding
inferred from electronic annotation with InterPro:IPR001628, InterPro:IPR013088
(InterPro Project Members, 2004-)
Biological Process (3 terms)
Terms Based on Experimental Evidence (2 terms)
CV Term
Evidence
References
involved_in central nervous system development
inferred from mutant phenotype
(Dittrich et al., 1997)
involved_in regulation of DNA-templated transcription
inferred from direct assay
(Dittrich et al., 1997)
Terms Based on Predictions or Assertions (2 terms)
CV Term
Evidence
References
involved_in regulation of DNA-templated transcription
inferred from electronic annotation with InterPro:IPR001628, InterPro:IPR013088
(InterPro Project Members, 2004-)
involved_in regulation of transcription by RNA polymerase II
inferred from biological aspect of ancestor with PANTHER:PTN001182563
(GO Reference Genome Project, 2011-)
Cellular Component (2 terms)
Terms Based on Experimental Evidence (0 terms)
Terms Based on Predictions or Assertions (2 terms)
CV Term
Evidence
References
is_active_in chromatin
inferred from biological aspect of ancestor with PANTHER:PTN002377694
(GO Reference Genome Project, 2011-)
is_active_in nucleus
inferred from biological aspect of ancestor with PANTHER:PTN001182563
(GO Reference Genome Project, 2011-)
Gene Group (FlyBase)
Protein Family (UniProt)
Belongs to the nuclear hormone receptor family. NR0 subfamily. (P15370)
Protein Signatures (InterPro)
Summaries
Gene Snapshot
eagle (eg) encodes a transcription factor of the nuclear hormone receptor subfamily O. Its roles include serotonergic differentiation (in combination with the product of hkb) and axonal pathfinding. [Date last reviewed: 2019-03-07]
Gene Group (FlyBase)
NUCLEAR RECEPTOR SUBFAMILY 0 (LIGAND-INDEPENDENT) TRANSCRIPTION FACTORS -
The nuclear receptor subfamily 0 (NR0) are C4 zinc finger sequence-specific DNA-binding proteins that regulate transcription. The NR0 subfamily are atypical, highly divergent members of the nuclear receptor superfamily that have only retained the DNA-binding domain. The absence of a ligand-binding domain suggests that NR0 transcription factors function in a ligand-independent manner. (Adapted from FBrf0086042 and FBrf0184203).
Protein Function (UniProtKB)
May play a critical role in development of the progeny of eagle-positive neuroblasts.
(UniProt, P15370)
Phenotypic Description (Red Book; Lindsley and Zimm 1992)
eg: eagle
Wings extended. Hairs on thorax somewhat disarranged. Dark pattern on thorax. Viability varies among alleles; eg2 females sterile. RK2.
Egon: Embryonic gonad
Expression detected in embryonic gonad but not in other tissues or at other stages of development.
Summary (Interactive Fly)

nuclear receptor - zinc finger - involved in the determination the cell fate of serotonergic neurons and axon pathfinding

Gene Model and Products
Number of Transcripts
3
Number of Unique Polypeptides
2

Please see the JBrowse view of Dmel\eg for information on other features

To submit a correction to a gene model please use the Contact FlyBase form

Protein Domains (via Pfam)
Isoform displayed:
Pfam protein domains
InterPro name
classification
start
end
Protein Domains (via SMART)
Isoform displayed:
SMART protein domains
InterPro name
classification
start
end
Structure
Protein 3D structure   (Predicted by AlphaFold)   (AlphaFold entry P15370)

If you don't see a structure in the viewer, refresh your browser.
Model Confidence:
  • Very high (pLDDT > 90)
  • Confident (90 > pLDDT > 70)
  • Low (70 > pLDDT > 50)
  • Very low (pLDDT < 50)

AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Some regions with low pLDDT may be unstructured in isolation.

Experimentally Determined Structures
Crossreferences
Comments on Gene Model

Gene model reviewed during 5.45

Transcript Data
Annotated Transcripts
Name
FlyBase ID
RefSeq ID
Length (nt)
Assoc. CDS (aa)
eg-RA
FBtr0078438
NM_079482
1800
373
eg-RB
FBtr0078437
NM_168938
1503
373
eg-RC
FBtr0332810
NM_001275264
1454
355
Additional Transcript Data and Comments
Reported size (kB)

2.2, 1.9 (compiled cDNA)

(Higashijima et al., 1996)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name
FlyBase ID
Predicted MW (kDa)
Length (aa)
Theoretical pI
UniProt
RefSeq ID
GenBank
eg-PA
FBpp0078092
39.6
373
8.68
P15370
NP_524206
AAF51783
eg-PB
FBpp0078091
39.6
373
8.68
P15370
NP_730689
AAN12188
eg-PC
FBpp0305033
37.7
355
9.36
M9PIJ7
NP_001262193
AGB94886
Polypeptides with Identical Sequences

The group(s) of polypeptides indicated below share identical sequence to each other.

373 aa isoforms: eg-PA, eg-PB
Additional Polypeptide Data and Comments
Reported size (kDa)

373 (aa)

(Higashijima et al., 1996)
Comments
External Data
Crossreferences
InterPro - A database of protein families, domains and functional sites
Linkouts
Sequences Consistent with the Gene Model
Mapped Features

Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\eg using the Feature Mapper tool.

External Data
Crossreferences
Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.
Linkouts
Expression Data
Testis-specificity index

The testis specificity index was calculated from modENCODE tissue expression data by Vedelek et al., 2018 to indicate the degree of testis enrichment compared to other tissues. Scores range from -2.52 (underrepresented) to 5.2 (very high testis bias).

4.14

Transcript Expression
in situ
Stage
Tissue/Position (including subcellular localization)
Reference
embryonic stage
neuroglioblast
(Bernardoni et al., 1999)
embryonic stage 1 -- 3
organism

Comment: maternally deposited

(Fisher et al., 2012)
embryonic stage 4 -- 6
organism | ubiquitous
(Fisher et al., 2012)
embryonic stage 11
neuroblast NB6-4 | punctate
(Bernardoni et al., 1999)
neuroblast NB2-4
(Chang et al., 2000)
neuroblast NB3-3
(Chang et al., 2000)
neuroblast NB6-4
(Chang et al., 2000)
neuroblast NB7-3
(Chang et al., 2000)
stage 5 neuroblast
(Chang et al., 2000)
embryonic stage 11 -- 12
neuroblast of ventral nervous system | subset
(Higashijima et al., 1996)
neuroblast NB2-4
(Higashijima et al., 1996)
neuroblast NB7-3
(Higashijima et al., 1996)
neuroblast NB3-3
(Higashijima et al., 1996)
presumptive embryonic/larval central nervous system | presumptive
(Higashijima et al., 1996)
neuroblast NB6-4
(Higashijima et al., 1996)
ventral nerve cord primordium
(Fisher et al., 2012)
embryonic stage 13 -- 16
larval ventral nerve cord
(Fisher et al., 2012)
embryonic stage 14
dorsal fold
(Higashijima et al., 1996)
Additional Descriptive Data

During stage 11-12 of embryogenesis, eg transcript is expressed in a subset of neuroblasts in the CNS. In neuroblasts NB2-4, NB3-3, and NB7-3, eg expression is strongest early, and during neuroblast delamination. Weak staining is also seen in some early progeny of neuroblast NB7-3 during stages 11-12. eg expression is not detected at or after stage 13.

(Higashijima et al., 1996)

In embryo, expressed in small number of CNS neuroblasts, starting late stage 10 or early 11 and observed through stage 12; in stage 14, expression observed in the dorsal sac.

(Higashijima et al., 1996)
Marker for
 
Subcellular Localization
CV Term
Polypeptide Expression
Expression Deduced from Reporters
Reporter: P{eg-kinesin-lacZ}
Stage
Tissue/Position (including subcellular localization)
Reference
embryonic stage
neuroblast of ventral nervous system | subset
(Higashijima et al., 1996)
embryonic stage -- larval stage
neuroblast NB6-4
(Lacin and Truman, 2016)
embryonic stage 10 -- 11
neuroblast NB2-4
(Higashijima et al., 1996)
neuroblast NB3-3
(Higashijima et al., 1996)
embryonic stage 11
neuroblast NB6-4
(Higashijima et al., 1996)
neuroblast NB7-3
(Higashijima et al., 1996)
Reporter: P{GawB}egMz360
Stage
Tissue/Position (including subcellular localization)
Reference
embryonic stage
neuroblast NB3-3
(Lacin and Truman, 2016, Tsuji et al., 2008)
neuroblast NB2-4
(Lacin and Truman, 2016)
neuroblast NB3-4
(Lacin and Truman, 2016)
neuroblast NB6-4
(Lacin and Truman, 2016)
neuroblast NB7-3
(Lacin and Truman, 2016)
embryonic stage -- larval stage
neuroblast NB3-4
(Lacin and Truman, 2016)
neuroblast NB7-3
(Lacin and Truman, 2016)
embryonic stage 11
serotonergic neuron | precursor
(Lundell and Hirsh, 1998)
embryonic stage 15
neuron of embryonic ventral nerve cord | restricted
(Joly et al., 2007)
embryonic stage 16
embryonic/larval cell body glial cell
(Ito et al., 1995)
CNS glial cell | restricted
(Ito et al., 1995)
presumptive embryonic/larval central nervous system | restricted
(Ito et al., 1995)
first instar larval stage
glial cell of larval central nervous system
(Ito et al., 1995)
larval central nervous system | restricted
(Ito et al., 1995)
second instar larval stage
neuroblast | subset
(Tsuji et al., 2008)
third instar larval stage
neuroblast | subset
(Tsuji et al., 2008)
Reporter: P{lacZ.w+}egP179
Stage
Tissue/Position (including subcellular localization)
Reference
embryonic stage 11 -- 12
neuroblast of ventral nervous system
(Higashijima et al., 1996)
Reporter: P{lArB}egP289
Stage
Tissue/Position (including subcellular localization)
Reference
embryonic stage 11
neuroblast NB7-3
(Lundell et al., 2003)
serotonergic neuron | precursor
(Lundell and Hirsh, 1998)
neuroblast | subset
(Badenhorst, 2001)
embryonic stage 12 -- 16
embryonic GW neuron
(Lundell et al., 2003)
embryonic stage 12 -- 17
larval EW neuron
(Lundell et al., 2003)
embryonic stage 15 -- 17
EW3 neuron
(Lundell et al., 2003, Dittrich et al., 1997)
EW2 neuron
(Lundell et al., 2003, Dittrich et al., 1997)
EW1 neuron
(Lundell et al., 2003, Dittrich et al., 1997)
embryonic GW neuron
(Lundell et al., 2003, Dittrich et al., 1997)
embryonic stage 16
serotonergic neuron
(Couch et al., 2004)
embryonic stage 17
EW1 neuron
(Lundell and Hirsh, 1998)
EW2 neuron
(Lundell and Hirsh, 1998)
EW3 neuron
(Lundell and Hirsh, 1998)
first instar larval stage
serotonergic neuron | subset
(Lundell and Hirsh, 1998)
larval serotonergic VNC neuron | subset
(Lundell and Hirsh, 1998)
larval ventral nerve cord | restricted
(Lundell and Hirsh, 1998)
High-Throughput Expression Data
Associated Tools

JBrowse - Visual display of RNA-Seq signals

View Dmel\eg in JBrowse
RNA-Seq by Region - Search RNA-Seq expression levels by exon or genomic region
Bulk Downloads
RNA-Seq RPKM values for all genes
Reference
See Gelbart and Emmert, 2013 for analysis details and data files for all genes.
Developmental Proteome: Life Cycle
Developmental Proteome: Embryogenesis
External Data and Images
Linkouts
BDGP expression data - Patterns of gene expression in Drosophila embryogenesis
DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species
EMBL-EBI Single Cell Expression Atlas - Single cell expression across species
FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data
Flygut - An atlas of the Drosophila adult midgut
Images
FlyBase Wiki
Image Based Resources
Alleles, Insertions, Transgenic Constructs, and Aberrations
Classical and Insertion Alleles ( 17 )
For All Classical and Insertion Alleles Show
 
Other relevant insertions
Transgenic Constructs ( 9 )
For All Alleles Carried on Transgenic Constructs Show
Transgenic constructs containing/affecting coding region of eg
Transgenic constructs containing regulatory region of eg
Aberrations (Deficiencies and Duplications) ( 2 )
Inferred from experimentation ( 2 )
Gene disrupted in
Df(3L)BSC450
(Christensen et al., 2008.4.15)
T(2;3)egspy
(Puro, 1982, Puro and Arajarvi, 1969)
Inferred from location ( 3 )
Variants
Variant Molecular Consequences
Alleles Representing Disease-Implicated Variants
Phenotypes
Orthologs
Downloads
Download All DIOPT Orthologs
Human Orthologs (via DIOPT v9.1)
Species\Gene Symbol
Score
Best Score
Best Reverse Score
Source
Compara
Domainoid
eggNOG
Hieranoid
Homologene
Inparanoid
OMA
OrthoDB
OrthoFinder
OrthoInspector
orthoMCL
Panther
Phylome
SonicParanoid
Alignment
Complementation?
Transgene?
Homo sapiens (Human) (36)
Hsap\ESR1
2 of 14
Yes
No
4  
Hsap\ESR2
2 of 14
Yes
No
Hsap\ESRRA
2 of 14
Yes
No
Hsap\ESRRB
2 of 14
Yes
No
Hsap\ESRRG
2 of 14
Yes
No
Hsap\AR
1 of 14
No
No
33  
Hsap\HNF4A
1 of 14
No
No
1  
Hsap\NR1D1
1 of 14
No
No
Hsap\NR1D2
1 of 14
No
No
1  
Hsap\NR1H4
1 of 14
No
No
Hsap\NR1I3
1 of 14
No
No
Hsap\NR2C1
1 of 14
No
No
1  
Hsap\NR2C2
1 of 14
No
No
Hsap\NR2E1
1 of 14
No
No
2  
Hsap\NR2F1
1 of 14
No
No
2  
Hsap\NR2F2
1 of 14
No
No
Hsap\NR2F6
1 of 14
No
No
Hsap\NR3C1
1 of 14
No
No
Hsap\NR3C2
1 of 14
No
No
Hsap\NR5A2
1 of 14
No
No
2  
Hsap\PGR
1 of 14
No
No
Hsap\PPARA
1 of 14
No
No
Hsap\PPARD
1 of 14
No
No
Hsap\PPARG
1 of 14
No
No
Hsap\RARA
1 of 14
No
No
Hsap\RARB
1 of 14
No
No
Hsap\RARG
1 of 14
No
No
Hsap\RORA
1 of 14
No
No
Hsap\RORB
1 of 14
No
No
Hsap\RORC
1 of 14
No
No
Hsap\RXRA
1 of 14
No
No
1  
Hsap\RXRB
1 of 14
No
No
Hsap\RXRG
1 of 14
No
No
Hsap\THRA
1 of 14
No
No
Hsap\THRB
1 of 14
No
No
Hsap\VDR
1 of 14
No
No
1  
Model Organism Orthologs (via DIOPT v9.1)
Species\Gene Symbol
Score
Best Score
Best Reverse Score
Source
Compara
Domainoid
eggNOG
Hieranoid
Homologene
Inparanoid
OMA
OrthoDB
OrthoFinder
OrthoInspector
orthoMCL
Panther
Phylome
SonicParanoid
Alignment
Complementation?
Transgene?
Rattus norvegicus (Norway rat) (17)
Rnor\Esr1
2 of 14
Yes
No
Rnor\Esr2
2 of 14
Yes
No
Rnor\Esrra
2 of 14
Yes
No
Rnor\Ar
1 of 14
No
No
Rnor\Esrrb
1 of 14
No
No
Rnor\Esrrg
1 of 14
No
No
Rnor\Nr1d2
1 of 14
No
No
Rnor\Nr2c2
1 of 14
No
No
Rnor\Nr2f6
1 of 14
No
No
Rnor\Nr3c1
1 of 14
No
No
Rnor\Nr3c2
1 of 14
No
No
Rnor\Pgr
1 of 14
No
No
Rnor\Ppara
1 of 14
No
No
Rnor\Pparg
1 of 14
No
No
Rnor\Rora
1 of 14
No
No
Rnor\Rorb
1 of 14
No
No
Rnor\Vdr
1 of 14
No
No
Mus musculus (laboratory mouse) (17)
Mmus\Esr1
2 of 14
Yes
No
Mmus\Esr2
2 of 14
Yes
No
Mmus\Esrra
2 of 14
Yes
No
Mmus\Ar
1 of 14
No
No
Mmus\Esrrb
1 of 14
No
No
Mmus\Esrrg
1 of 14
No
No
Mmus\Nr1d2
1 of 14
No
No
Mmus\Nr2c2
1 of 14
No
No
Mmus\Nr2f6
1 of 14
No
No
Mmus\Nr3c1
1 of 14
No
No
Mmus\Nr3c2
1 of 14
No
No
Mmus\Pgr
1 of 14
No
No
Mmus\Ppara
1 of 14
No
No
Mmus\Pparg
1 of 14
No
No
Mmus\Rora
1 of 14
No
No
Mmus\Rorb
1 of 14
No
No
Mmus\Vdr
1 of 14
No
No
Xenopus tropicalis (Western clawed frog) (25)
Xtro\esr1
2 of 13
Yes
Yes
Xtro\esr2
2 of 13
Yes
Yes
Xtro\esrra
2 of 13
Yes
No
Xtro\esrrb
2 of 13
Yes
No
Xtro\esrrgr
2 of 13
Yes
No
Xtro\ar
1 of 13
No
No
Xtro\banf1
1 of 13
No
No
Xtro\cnpy2
1 of 13
No
No
Xtro\nr1d1
1 of 13
No
No
Xtro\nr1h2
1 of 13
No
No
Xtro\nr1h4
1 of 13
No
No
Xtro\nr1h5
1 of 13
No
No
Xtro\nr1i2
1 of 13
No
No
Xtro\nr2c1
1 of 13
No
No
Xtro\nr2e1
1 of 13
No
No
Xtro\nr2e3
1 of 13
No
No
Xtro\nr2f2
1 of 13
No
No
Xtro\nr2f5
1 of 13
No
No
Xtro\nr3c2
1 of 13
No
No
Xtro\nr6a1
1 of 13
No
No
Xtro\pgr
1 of 13
No
No
Xtro\ppara
1 of 13
No
No
Xtro\rarb
1 of 13
No
No
Xtro\ubxn6
1 of 13
No
No
Xtro\vdr
1 of 13
No
No
Danio rerio (Zebrafish) (31)
Drer\esr2a
2 of 14
Yes
No
Drer\ar
1 of 14
No
No
Drer\esr1
1 of 14
No
No
Drer\esr2b
1 of 14
No
No
Drer\esrra
1 of 14
No
No
Drer\esrrb
1 of 14
No
No
Drer\esrrga
1 of 14
No
No
Drer\esrrgb
1 of 14
No
No
Drer\nr1d1
1 of 14
No
No
Drer\nr1d2a
1 of 14
No
No
Drer\nr1d2b
1 of 14
No
No
Drer\nr1d4a
1 of 14
No
No
Drer\nr1d4b
1 of 14
No
No
Drer\nr2c1
1 of 14
No
No
Drer\nr2c2
1 of 14
No
No
Drer\nr2f5
1 of 14
No
No
Drer\nr2f6a
1 of 14
No
No
Drer\nr3c1
1 of 14
No
No
Drer\nr3c2
1 of 14
No
No
Drer\pgr
1 of 14
No
No
Drer\pparaa
1 of 14
No
No
Drer\pparab
1 of 14
No
No
Drer\ppardb
1 of 14
No
No
Drer\roraa
1 of 14
No
No
Drer\rorab
1 of 14
No
No
Drer\rorb
1 of 14
No
No
Drer\rorca
1 of 14
No
No
Drer\rorcb
1 of 14
No
No
Drer\rorc
1 of 14
No
No
Drer\vdra
1 of 14
No
No
Drer\vdrb
1 of 14
No
No
Caenorhabditis elegans (Nematode, roundworm) (37)
Cele\nhr-179
2 of 14
Yes
Yes
Cele\nhr-201
2 of 14
Yes
Yes
Cele\nhr-6
1 of 14
No
No
Cele\nhr-14
1 of 14
No
No
Cele\nhr-17
1 of 14
No
No
Cele\nhr-19
1 of 14
No
No
Cele\nhr-23
1 of 14
No
No
Cele\nhr-32
1 of 14
No
No
Cele\nhr-41
1 of 14
No
No
Cele\nhr-49
1 of 14
No
No
Cele\nhr-54
1 of 14
No
No
Cele\nhr-59
1 of 14
No
No
Cele\nhr-61
1 of 14
No
No
Cele\nhr-64
1 of 14
No
No
Cele\nhr-85
1 of 14
No
No
Cele\nhr-88
1 of 14
No
No
Cele\nhr-91
1 of 14
No
No
Cele\nhr-95
1 of 14
No
No
Cele\nhr-96
1 of 14
No
No
Cele\nhr-99
1 of 14
No
No
Cele\nhr-100
1 of 14
No
No
Cele\nhr-110
1 of 14
No
No
Cele\nhr-119
1 of 14
No
No
Cele\nhr-125
1 of 14
No
No
Cele\nhr-127
1 of 14
No
No
Cele\nhr-128
1 of 14
No
No
Cele\nhr-133
1 of 14
No
No
Cele\nhr-177
1 of 14
No
No
Cele\nhr-183
1 of 14
No
No
Cele\nhr-195
1 of 14
No
No
Cele\nhr-202
1 of 14
No
No
Cele\nhr-203
1 of 14
No
No
Cele\nhr-207
1 of 14
No
No
Cele\nhr-208
1 of 14
No
No
Cele\nhr-211
1 of 14
No
No
Cele\nhr-213
1 of 14
No
No
Cele\nhr-231
1 of 14
No
No
Anopheles gambiae (African malaria mosquito) (10)
Agam\AgaP_AGAP010438
3 of 12
Yes
No
Agam\AgaP_AGAP000819
1 of 12
No
No
Agam\AgaP_AGAP001348
1 of 12
No
No
Agam\AgaP_AGAP001743
1 of 12
No
No
Agam\AgaP_AGAP002544
1 of 12
No
No
Agam\AgaP_AGAP005661
1 of 12
No
No
Agam\AgaP_AGAP006571
1 of 12
No
No
Agam\AgaP_AGAP008334
1 of 12
No
No
Agam\AgaP_AGAP009002
1 of 12
No
No
Agam\AgaP_AGAP009575
1 of 12
No
No
Arabidopsis thaliana (thale-cress) (0)
Saccharomyces cerevisiae (Brewer's yeast) (0)
Schizosaccharomyces pombe (Fission yeast) (0)
Escherichia coli (enterobacterium) (0)
Other Organism Orthologs (via OrthoDB)
Data provided directly from OrthoDB:eg. Refer to their site for version information.
Paralogs
Downloads
Download All DIOPT Paralogs
Paralogs (via DIOPT v9.1)
Gene Symbol
Score
Source
Compara
Domainoid
eggNOG
Homologene
Inparanoid
OMA
OrthoDB
OrthoFinder
OrthoInspector
orthoMCL
Panther
Phylome
SonicParanoid
Alignment
Drosophila melanogaster (Fruit fly) (10)
knrl
6 of 13
kni
5 of 13
ERR
2 of 13
dsf
1 of 13
Eip75B
1 of 13
Eip78C
1 of 13
Hr3
1 of 13
Hr4
1 of 13
svp
1 of 13
tll
1 of 13
Human Disease Associations
FlyBase Human Disease Model Reports
    Disease Ontology (DO) Annotations
    Models Based on Experimental Evidence ( 0 )
    Allele
    Disease
    Evidence
    References
    Potential Models Based on Orthology ( 0 )
    Human Ortholog
    Disease
    Evidence
    References
    Modifiers Based on Experimental Evidence ( 0 )
    Allele
    Disease
    Interaction
    References
    Disease Associations of Human Orthologs (via DIOPT v9.1 and OMIM)
    Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.
    Homo sapiens (Human)
    Gene name
    Score
    OMIM
    OMIM Phenotype
    DO term
    Complementation?
    Transgene?
    Functional Complementation Data
    Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.
    Interactions
    Summary of Physical Interactions
    Summary of Genetic Interactions
    Interaction Browsers
    View in FlyBase Interactions Browser   View in MIST tool (external link)
    Please look at the allele data for full details of the genetic interactions
    Starting gene(s)
    Interaction type
    Interacting gene(s)
    Reference
    eg
    suppressible
    hkb
    (Dittrich et al., 1997)
    eg
    suppressible
    robo2
    (Couch et al., 2004)
    Starting gene(s)
    Interaction type
    Interacting gene(s)
    Reference
    kni
    suppressible
    eg
    (Lunde et al., 2003)
    Ras85D
    suppressible
    eg
    (Hay et al., 1997)
    rl
    enhanceable
    eg
    (Gritzan et al., 2002)
    robo2
    suppressible
    eg
    (Couch et al., 2004)
    External Data
    Linkouts
    BioGRID - A database of protein and genetic interactions.
    DroID - A comprehensive database of gene and protein interactions.
    MIST (protein-protein) - An integrated Molecular Interaction Database
    Pathways
    Class of Gene
    Genomic Location and Detailed Mapping Data
    Chromosome (arm)
    3L
    Recombination map
    3-47
    Cytogenetic map
    78F2-78F3
    Sequence location
    FlyBase Computed Cytological Location
    Cytogenetic map
    Evidence for location
    78F2-78F3
    Limits computationally determined from genome sequence between P{lacW}l(3)j1B10j1B10 and P{lacW}l(3)j2C4j2C4
    Experimentally Determined Cytological Location
    Cytogenetic map
    Notes
    References
    79A3-79A4
    (determined by in situ hybridisation)
    (Hay et al., 1997)
    79B-79B
    (determined by in situ hybridisation)
    (Rothe et al., 1989)
    Experimentally Determined Recombination Data
    Location

    3-47

    (FlyBase, 2016)

    3-44.0

    (Comeron et al., 2012)

    3-47.3

    (Duncan and Kaufman, 1975)
    Left of (cM)
    Right of (cM)
    (Puro and Nygren, 1975)
    Notes
    Stocks and Reagents
    Stocks (33)
    Genomic Clones (17)
     

    Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete

    cDNA Clones (3)
     

    Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see JBrowse for alignment of the cDNAs and ESTs to the gene model.

    cDNA clones, fully sequenced
    BDGP DGC clones
      Other clones
      Drosophila Genomics Resource Center cDNA clones

      For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.

      cDNA Clones, End Sequenced (ESTs)
      BDGP DGC clones
        Other clones
        RNAi and Array Information
        Linkouts
        DRSC - Results frm RNAi screens
        Antibody Information
        Laboratory Generated Antibodies
         

        monoclonal

        (Karcavich and Doe, 2005, Couch et al., 2004)

        polyclonal

        (Karcavich and Doe, 2005)
        Commercially Available Antibodies
         
        Cell Line Information
        Publicly Available Cell Lines
         
          Other Stable Cell Lines
           
            Other Comments

            Mutant allele fails to complement a QTL affecting male mating behaviour.

            (Moehring and Mackay, 2004)

            eg is essential for specifying the fate of serotonin neurons. eg is necessary for the maintenance of en and zfh2 expression in the serotonin neurons.

            (Lundell and Hirsh, 1998)

            Loss of function eg mutations produce an unusual differential phenotype with respect to the sister serotonin cells. Hypomorphic alleles can produce viable adults that have a dramatic reduction in the number of serotonin-producing neurons.

            (Lundell and Hirsh, 1998)

            eg and hkb act in concert to determine serotonergic cell fate in the developing central nervous system.

            (Dittrich et al., 1997)

            eg is isolated and characterised, eg RNA expression is restricted to 4 neuroblasts and a part of their putative progeny.

            (Higashijima et al., 1996)

            Evolutionary history for nuclear receptor genes, in which gene duplication events and swapping between domains of different origins took place, is studied.

            (Laudet et al., 1992)

            Mutant individuals display spread wings.

            (Duncan and Kaufman, 1975)

            Egon first isolated from genomic library using a kni zinc-finger probe. Expression detected in embryonic gonad but not in other tissues or at other stages of development.

            Relationship to Other Genes
            Source for database merge of

            Source for merge of: eg egon

            (Higashijima et al., 1996)
            Additional comments
            Nomenclature History
            Source for database identify of
            Nomenclature comments
            Etymology
            Synonyms and Secondary IDs (18)
            Reported As
            Symbol Synonym
            CG7383
            (Hosono et al., 2015, Ni et al., 2011.7.19, Perkins et al., 2009)
            EGON
            (Laudet et al., 1992)
            Eg
            (Rickert et al., 2018, Geyer et al., 2015, Birkholz et al., 2013, Berger et al., 2010, Kannan et al., 2010, Galindo et al., 2009, Rogulja-Ortmann et al., 2007)
            Egl
            (Hinnant et al., 2020, Garbe et al., 2007)
            Egon
            NR0A3
            (Nuclear Receptors Nomenclature Committee, 1999)
            T1
            (Higashijima et al., 1996)
            eag
            (Broadus et al., 1995)
            eagle
            (Lüer and Technau, 2009)
            eg
            (Lee et al., 2024, Wu et al., 2024, Pegoraro et al., 2022, Huang and Ryoo, 2021, Hall et al., 2019, Shokri et al., 2019, Arbeille and Bashaw, 2018, Bischof et al., 2018, Shen et al., 2018, Transgenic RNAi Project members, 2017-, Becker et al., 2016, model organism Encyclopedia of Regulatory Network (modERN) Project, 2015-, Schertel et al., 2015, O'Donnell and Bashaw, 2013, Chen and Condron, 2009, Rodriguez Moncalvo and Campos, 2009, Ruedi and Hughes, 2009, Song et al., 2009, Anaka et al., 2008, Christensen et al., 2008.4.15, Kim et al., 2008, Rogulja-Ortmann et al., 2008, Stofanko et al., 2008, Tsuji et al., 2008, Jung et al., 2007, Kim et al., 2007, Lee and Lundell, 2007, Buescher et al., 2006, Kang et al., 2006, Karcavich and Doe, 2005)
            egl
            (Mauss et al., 2009, Yang et al., 2009, Garbe and Bashaw, 2007)
            egon
            (Henrich and Brown, 1995, Thummel, 1995, Gerwin et al., 1994, Oro et al., 1992, Segraves, 1991, Henrich et al., 1990)
            spy
            (Puro and Arajarvi, 1969)
            Name Synonyms
            Eagle
            (Geyer et al., 2015, Birkholz et al., 2013, Unhavaithaya et al., 2013, Kohwi et al., 2011, Kannan et al., 2010, Palgi et al., 2009, Soustelle et al., 2008, Lee and Lundell, 2007, Kanai et al., 2005, Cheesman et al., 2004)
            Embryonic gonad
            T1 transcription unit
            (Higashijima et al., 1996)
            eagle
            (Brenman-Suttner et al., 2020, Rickert et al., 2018, O'Donnell and Bashaw, 2013, Nfonsam et al., 2012, Mauss et al., 2009, Rodriguez Moncalvo and Campos, 2009, Ruedi and Hughes, 2009, Yang et al., 2009, Anaka et al., 2008, Colomb et al., 2008, Kim et al., 2008, Rogulja-Ortmann et al., 2008, Stofanko et al., 2008, Tsuji et al., 2008, Garbe et al., 2007, Kim et al., 2007, Girard et al., 2006, Karcavich and Doe, 2005, Saigo, 1994.11.26, Saigo, 1994.11.26)
            eg
            (Shen et al., 2018)
            embryonic gonad
            (Oro et al., 1992)
            spready
            Secondary FlyBase IDs
            • FBgn0000563
            Datasets (0)
            Study focus (0)
            Experimental Role
            Project
            Project Type
            Title
            Study result (0)
            Result
            Result Type
            Title
            External Crossreferences and Linkouts ( 57 )
            Sequence Crossreferences
            NCBI Gene - Gene integrates information from a wide range of species. A record may include nomenclature, Reference Sequences (RefSeqs), maps, pathways, variations, phenotypes, and links to genome-, phenotype-, and locus-specific resources worldwide.
            GenBank Nucleotide - A collection of sequences from several sources, including GenBank, RefSeq, TPA, and PDB.
            GenBank Protein - A collection of sequences from several sources, including translations from annotated coding regions in GenBank, RefSeq and TPA, as well as records from SwissProt, PIR, PRF, and PDB.
            RefSeq - A comprehensive, integrated, non-redundant, well-annotated set of reference sequences including genomic, transcript, and protein.
            UniProt/GCRP - The gene-centric reference proteome (GCRP) provides a 1:1 mapping between genes and UniProt accessions in which a single 'canonical' isoform represents the product(s) of each protein-coding gene.
            UniProt/Swiss-Prot - Manually annotated and reviewed records of protein sequence and functional information
            UniProt/TrEMBL - Automatically annotated and unreviewed records of protein sequence and functional information
            Other crossreferences
            AlphaFold DB - AlphaFold provides open access to protein structure predictions for the human proteome and other key proteins of interest, to accelerate scientific research.
            BDGP expression data - Patterns of gene expression in Drosophila embryogenesis
            DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species
            EMBL-EBI Single Cell Expression Atlas - Single cell expression across species
            FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data
            FlyMine - An integrated database for Drosophila genomics
            InterPro - A database of protein families, domains and functional sites
            KEGG Genes - Molecular building blocks of life in the genomic space.
            MARRVEL_MODEL - MARRVEL (model organism gene)
            Linkouts
            BioGRID - A database of protein and genetic interactions.
            Drosophila Genomics Resource Center - Drosophila Genomics Resource Center (DGRC) cDNA clones
            DroID - A comprehensive database of gene and protein interactions.
            DRSC - Results frm RNAi screens
            Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.
            FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
            FlyCyc Genes - Genes from a BioCyc PGDB for Dmel
            Flygut - An atlas of the Drosophila adult midgut
            FlyMet - A comprehensive tissue-specific metabolomics resource for Drosophila.
            iBeetle-Base - RNAi phenotypes in the red flour beetle (Tribolium castaneum)
            Interactive Fly - A cyberspace guide to Drosophila development and metazoan evolution
            MIST (protein-protein) - An integrated Molecular Interaction Database
            Reactome - An open-source, open access, manually curated and peer-reviewed pathway database.
            References (157)