FlyBase Allele Report: Dmel\Ttc7[k15603]

General Information

Symbol

Dmel\Ttc7^k15603

Species

D. melanogaster

Name

FlyBase ID

FBal0064094

Feature type

allele

Associated gene

Dmel\Ttc7

Associated Insertion(s)

P{lacW}Ttc7^k15603

Carried in Construct

Key Links

Genomic Maps

JBrowse

Allele class

Mutagen

P-element activity

Nature of the Allele

Allele class

Mutagen

P-element activity

(BDGP Project Members, 1994-1999)

Progenitor genotype

Associated Insertion(s)

P{lacW}Ttc7^k15603

Cytology

Description

Allele components

Component

Use(s)

Inserted element

P{lacW}

enhancer trap

Encoded product / tool

lacZ

reporter enzyme

Tagged with

Tag:NLS(P)

nuclear protein localization tag

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

transposable_element_insertion_site

2R:6,214,072..6,214,072 [+]

(Zhang et al., 2022, Sun et al., 2018, Peifer, 2001.8.3, Spradling et al., 1999, BDGP Project Members, 1994-1999)

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 1 )

Disease

Interaction

References

ameliorates Alzheimer's disease

modeled by Hsap\APP^{Aβ42.UAS.Tag:SS(nec)}

(Sun et al., 2018)

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

lethal | recessive

(Spradling et al., 1999, BDGP Project Members, 1994-1999)

Phenotype Manifest In

Detailed Description

Statement

Reference

Ttc7^k15603 heterozygous do not show significant decreases in lifespan, in climbing ability or in neurotransmission to DM muscles, as compared to controls.

(Sun et al., 2018)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Suppressor of

Statement

Reference

Ttc7^k15603/Ttc7[+] is a suppressor of abnormal locomotor behavior | adult stage phenotype of Hsap\APP^{Aβ42.UAS.Tag:SS(nec)}, Scer\GAL4^shot-OK307

(Sun et al., 2018)

Ttc7^k15603/Ttc7[+] is a suppressor of short lived phenotype of Hsap\APP^{Aβ42.UAS.Tag:SS(nec)}, Scer\GAL4^shot-OK307

(Sun et al., 2018)

Ttc7^k15603/Ttc7[+] is a suppressor of abnormal neurophysiology | adult stage phenotype of Hsap\APP^{Aβ42.UAS.Tag:SS(nec)}, Scer\GAL4^shot-OK307

(Sun et al., 2018)

Phenotype Manifest In

Suppressor of

Statement

Reference

Ttc7^k15603/Ttc7[+] is a suppressor of dorsal longitudinal indirect flight muscle cell phenotype of Hsap\APP^{Aβ42.UAS.Tag:SS(nec)}, Scer\GAL4^shot-OK307

(Sun et al., 2018)

Additional Comments

Genetic Interactions

Statement

Reference

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Fails to complement

Ttc7^k14710

(BDGP Project Members, 1994-1999)

Ttc7^k15616

(BDGP Project Members, 1994-1999)

Comments

Images (0)

Mutant

Wild-type

Stocks (2)

Bloomington

11134

y¹ w^67c23; P{lacW}Ttc7^k15603/CyO

Kyoto

102966

y¹ w^67c23 ; P{lacW}Ttc7^k15603 / CyO

Notes on Origin

Discoverer

I. Kiss.

(BDGP Project Members, 1994-1999)

Comments

Complements: EcR^k04504. Complements: EcR^k06210. Complements: l(2)k09848^k09848. Complements: l(2)k14805^k14805.

(BDGP Project Members, 1994-1999)

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (3)

Reported As

Symbol Synonym

Ttc7^k15603

l(2)k14710^k15603

(Christensen et al., 2007.10.29)

l(2)k15603

(Peifer, 2001.8.3, Spradling et al., 1999)

Name Synonyms

Secondary FlyBase IDs

References (7)

Report Sections

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