FlyBase Allele Report: Dmel\arr[k08131]

General Information

Symbol

Dmel\arr^k08131

Species

D. melanogaster

Name

FlyBase ID

FBal0064341

Feature type

allele

Associated gene

Dmel\arr

Associated Insertion(s)

P{lacW}arr^k08131

Carried in Construct

Also Known As

l(2)k08131

Key Links

Allele class

Mutagen

P-element activity

Nature of the Allele

Allele class

Mutagen

P-element activity

(BDGP Project Members, 1994-1999)

Progenitor genotype

Associated Insertion(s)

P{lacW}arr^k08131

Cytology

Description

Insertion in the 5'UTR sequence, in the first untranslated exon.

(Schilling et al., 2014)

Allele components

Component

Use(s)

Inserted element

P{lacW}

enhancer trap

Encoded product / tool

lacZ

reporter enzyme

Tagged with

Tag:NLS(P)

nuclear protein localization tag

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

abnormal neuroanatomy | larval stage (with arr²)

(Huang et al., 2018)

lethal | recessive

(BDGP Project Members, 1994-1999)

Phenotype Manifest In

embryonic/larval neuromuscular junction (with arr²)

(Huang et al., 2018)

terminal bouton | larval stage (with arr²)

(Huang et al., 2018)

Detailed Description

Statement

Reference

arr²/arr^k08131 larvae have significantly reduced bouton number and significantly increased bouton size at the neuromuscular junction of muscle 4, compared to controls.

(Huang et al., 2018)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Suppressor of

Statement

Reference

arr^k08131/arr² is a suppressor of abnormal neuroanatomy | larval stage phenotype of nwk²

(Rodal et al., 2011)

Phenotype Manifest In

Suppressor of

Statement

Reference

arr^k08131/arr² is a suppressor of NMJ bouton | increased number | larval stage phenotype of nwk²

(Rodal et al., 2011)

Additional Comments

Genetic Interactions

Statement

Reference

The increase in average satellite bouton number at the neuromuscular junction which is seen in nwk² larvae is suppressed if they are also carrying arr^k08131/arr².

(Rodal et al., 2011)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Fails to complement

arr^unspecified

(Wehrli et al., 2000)

Comments

Images (0)

Mutant

Wild-type

Stocks (1)

Bloomington

665

y¹ w^67c23; P{lacW}arr^k08131/CyO

Notes on Origin

Discoverer

I. Kiss.

(BDGP Project Members, 1994-1999)

Comments

This allele was listed in the BDGP database as a lethal or sterile line during the period 1994-1999, but was discarded from the gene disruption project prior to the summary publication (FBrf0111489). Reasons for excluding lines from the collection described in FBrf0111489 include presence of more than one P insertion on the mutant chromosome, separation of lethality (or sterility) from the location of the insertion, and loss of lethality (or sterility) from the stock. Further information is available from http://www.fruitfly.org/bfd/ and from Dr. Spradling (spradling@mail1.ciwemb.edu).

Complements: drk¹⁰⁶²⁶. Complements: drk^k02401. Complements: drk^k03106. Complements: shot^k05434b.

(BDGP Project Members, 1994-1999)

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (5)

Reported As

Symbol Synonym

arr^K08131

(Rodal et al., 2011)

arr^k08131

(Huang et al., 2018)

arr^k0813

(Huang et al., 2018)

l(2)k08131

(Schilling et al., 2014, Wehrli, 2000.10.22, Wehrli et al., 2000)

l(2)k08131^k08131

(BDGP Project Members, 1994-1999)

Name Synonyms

Secondary FlyBase IDs

References (7)

Report Sections

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