FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\arrunspecified
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General Information
Symbol
Dmel\arrunspecified
Species
D. melanogaster
Name
FlyBase ID
FBal0086714
Feature type
allele
Associated gene
Dmel\arr
Associated Insertion(s)
Carried in Construct
Key Links
Allele class
Mutagen
    Nature of the Allele
    Allele class
    Mutagen
    Progenitor genotype
    Cytology
    Description

    FlyBase curator comment: this entry is used to capture phenotypic information when the particular allele (or allele combination) used by the author could not be determined but the context of the experiment suggests that the phenotype being described is some kind of loss of function.

    (FlyBase Curators, 2025-)
    Mutations Mapped to the Genome
    Curation Data
    Type
    Location
    Additional Notes
    References
    Variant Molecular Consequences
    Associated Sequence Data
    DDBJ / EMBL / GenBank
    DNA sequence
    Protein sequence
     
    UniProtKB/Swiss-Prot
      UniProtKB/TrEMBL
        Expression Data
        Reporter Expression
        Additional Information
        Statement
        Reference
         
        Marker for
        Reflects expression of
        Reporter construct used in assay
        Human Disease Associations
        Disease Ontology (DO) Annotations
        Models Based on Experimental Evidence ( 0 )
        Disease
        Evidence
        References
        Modifiers Based on Experimental Evidence ( 0 )
        Disease
        Interaction
        References
        Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
         
        Disease-implicated variant(s)
         
        Phenotypic Data
        Phenotypic Class
        Phenotype Manifest In
        Detailed Description
        Statement
        Reference

        Heterozygous embryos derived from homozygous female germline clones show normal accumulation of glycogen at all stages.

        (Yamazaki and Yanagawa, 2003)

        The anterior en-expressing cells in each segment incorrectly adopt a denticle fate in zygotic arr mutants. Embryos lacking both maternal and zygotic arr function are indistinguishable from wg null mutants. No smooth cuticle is produced in these embryos. arr null mutant cells do not survive as well as their wild-type sister cells when twin spot clones are made. Mutant clones in the dorsal leg show no tissue polarity defects.

        (Wehrli et al., 2000)

        arrunspecified mutant embryos have additional denticle bands anterior and posterior to the normal denticle bands, especially in the ventral midline. The phenotype is stronger at 18oC.

        (Tearle and Nusslein-Volhard, 1987)
        External Data
        Interactions
        Show genetic interaction network for Enhancers & Suppressors
        Phenotypic Class
        Phenotype Manifest In
        Suppressed by
        Additional Comments
        Genetic Interactions
        Statement
        Reference

        Smooth cuticle is restored in alternate segments to arrunspecified embryos lacking maternal and zygotic arr function when dshScer\UAS.cAa is expressed in these embryos under the control of Scer\GAL4prd.RG1. Overexpression of wg has no effect on the phenotype of embryos lacking maternal and zygotic arr function.

        (Wehrli et al., 2000)
        Xenogenetic Interactions
        Statement
        Reference
        Complementation and Rescue Data
        Fails to complement

        arrk08131

        (Wehrli et al., 2000)
        Rescued by

        arrunspecified is rescued by Scer\GAL4prd.RG1/arrUAS.cRa.Tag:HA

        (Rives et al., 2006)
        Partially rescued by

        arrunspecified is partially rescued by Scer\GAL4prd.RG1/arrUAS.cWa

        (Wehrli et al., 2000)
        Comments
        Images (0)
        Mutant
        Wild-type
        Stocks (0)
        Notes on Origin
        Discoverer
        External Crossreferences and Linkouts ( 0 )
        Synonyms and Secondary IDs (1)
        Reported As
        Symbol Synonym
        arrunspecified
        Name Synonyms
        Secondary FlyBase IDs
          References (7)