FlyBase Allele Report: Dmel\wcd[k07824]

General Information

Symbol

Dmel\wcd^k07824

Species

D. melanogaster

Name

FlyBase ID

FBal0064366

Feature type

allele

Associated gene

Dmel\wcd

Associated Insertion(s)

P{lacW}wcd^k07824

Carried in Construct

Also Known As

l(2)k07824

Key Links

Genomic Maps

JBrowse

Allele class

Mutagen

P-element activity

Nature of the Allele

Allele class

Mutagen

P-element activity

(BDGP Project Members, 1994-1999)

Progenitor genotype

Associated Insertion(s)

P{lacW}wcd^k07824

Cytology

Description

Insertion 68bp downstream of the start site.

(Fichelson et al., 2009, Fichelson et al., 2009)

Allele components

Component

Use(s)

Inserted element

P{lacW}

enhancer trap

Encoded product / tool

lacZ

reporter enzyme

Tagged with

Tag:NLS(P)

nuclear protein localization tag

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

transposable_element_insertion_site

2R:16,347,326..16,347,326 [+]

(Fichelson et al., 2009, Fichelson et al., 2009, Spradling et al., 1999, BDGP Project Members, 1994-1999)

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 1 )

Disease

Interaction

References

ameliorates autosomal dominant cerebellar ataxia

modeled by Hsap\ATXN8OS^CTG112.UAS

(Mutsuddi et al., 2004)

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

lethal

(Fichelson et al., 2009)

lethal (with Df(2R)BSC550)

(Kahsai et al., 2016)

lethal | recessive

(Spradling et al., 1999, BDGP Project Members, 1994-1999)

Phenotype Manifest In

female germline stem cell | germline clone

(Fichelson et al., 2009)

ganglion cell | somatic clone

(Fichelson et al., 2009)

neuroblast | somatic clone

(Fichelson et al., 2009)

Detailed Description

Statement

Reference

The rate of loss of homozygous wcd^k07824 germline stem cell clones (GSCs) in the ovary as females age is much more pronounced than the rate of loss of wild-type GSCs as females age.

Homozygous ventral nerve cord neuroblast clones produce fewer ganglion cells than wild-type neuroblast clones. The mutant neuroblasts are on average half the size of wild-type neuroblasts.

(Fichelson et al., 2009)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Suppressor of

Statement

Reference

l(2)k07824[+]/wcd^k07824 is a suppressor of abnormal neuroanatomy phenotype of Hsap\ATXN8OS^CTG112.UAS, Scer\GAL4^GMR.PF

(Mutsuddi et al., 2004)

Phenotype Manifest In