FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\HnRNP-Kk08305
Open Close
General Information
Symbol
Dmel\HnRNP-Kk08305
Species
D. melanogaster
Name
FlyBase ID
FBal0064710
Feature type
allele
Associated gene
Dmel\HnRNP-K
Associated Insertion(s)
P{lacW}HnRNP-Kk08305
Carried in Construct
Key Links
Genomic Maps

Allele class
Mutagen
Nature of the Allele
Allele class
Mutagen
P-element activity
(BDGP Project Members, 1994-1999)
Progenitor genotype
Associated Insertion(s)
P{lacW}HnRNP-Kk08305
Cytology
Description

P{lacW} insertion within the first intron, 792bp downstream of the 5' splice site.

(Gates and Thummel, 2000)
Allele components
Component
Use(s)
Inserted element
P{lacW}
Encoded product / tool
lacZ
Tagged with
Tag:NLS(P)
Mutations Mapped to the Genome
Curation Data
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Homozygotes show little or no embryonic lethality. The majority of the lethality occurs during early pupal and pharate adult stages. Some homozygous adults are able to eclose, but they die 2 to 3 days later. Homozygous pharate adults have malformed legs, which display a range of phenotypes, including being both short and bent or curved around the edge of the wing. The basitarsus may be short and thick and the femur may contain constrictions. 46% of mutant mid-prepupae have at least one malformed leg, 78% of mutant pupae and adults have at least one malformed leg. blv5/blk08305 animals have severely malformed legs.

      (Gates and Thummel, 2000)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      NOT Suppressor of
      Statement
      Reference

      HnRNP-Kk08305/bl[+] is a non-suppressor of male germline cell phenotype of maelM391/Df(3L)79E-F

      (Pek et al., 2009)
      Additional Comments
      Genetic Interactions
      Statement
      Reference

      The differentiation defects seen in the testes of maelM391/Df(3L)79E-F males are not rescued by blk08305/+.

      (Pek et al., 2009)
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Fails to complement

      HnRNP-Kv5

      (Gates and Thummel, 2000)
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (1)
      Notes on Origin
      Discoverer

      I. Kiss.

      (BDGP Project Members, 1994-1999)
      Comments
      Comments

      This allele was listed in the BDGP database as a lethal or sterile line during the period 1994-1999, but was discarded from the gene disruption project prior to the summary publication (FBrf0111489). Reasons for excluding lines from the collection described in FBrf0111489 include presence of more than one P insertion on the mutant chromosome, separation of lethality (or sterility) from the location of the insertion, and loss of lethality (or sterility) from the stock. Further information is available from http://www.fruitfly.org/bfd/ and from Dr. Spradling (spradling@mail1.ciwemb.edu).

      Excision of the P{lacW} element can result in reversion of the phenotype.

      (Gates and Thummel, 2000)

      Complements: rig05056. Complements: rigk07839. Complements: rigk07917. "l(2)05056" was originally reported as an allele of bl, but "l(2)05056" complements blk08305. In addition, "l(2)k07917" and "l(2)k07839" fail to complement "l(2)05056" and complement blk08305. "l(2)05056", "l(2)k07917" and "l(2)k07839" therefore constitute a lethal complementation group that is distinct from bl and this complementation group is referred to as "rig".

      (Gates et al., 2004)

      Complements: l(2)0551005510. Complements: l(2)k09920k09920. Complements: l(2)k16204k16204. Complements: l(2)s4831s4831.

      (BDGP Project Members, 1994-1999)
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (5)
      Reported As
      Symbol Synonym
      HnRNP-Kk08305
      bancalk08305
      (Pek et al., 2009)
      blk08305
      l(2)05056k08305
      (BDGP Project Members, 1994-1999)
      l(2)k08305
      (Gates and Thummel, 2000)
      Name Synonyms
      Secondary FlyBase IDs
        References (4)