FlyBase Allele Report: Dmel\lqf[bE248]

General Information

Symbol

Dmel\lqf^bE248

Species

D. melanogaster

Name

FlyBase ID

FBal0066109

Feature type

allele

Associated gene

Dmel\lqf

Associated Insertion(s)

Carried in Construct

Key Links

Genomic Maps

JBrowse

Allele class

Mutagen

ethyl methanesulfonate

Nature of the Allele

Allele class

Mutagen

ethyl methanesulfonate

(Cadavid et al., 2000, Fischer et al., 1997)

Progenitor genotype

Cytology

Description

Amino acid replacement: Q2term.

(Overstreet et al., 2003)

Nucleotide substitution: C?T.

(Overstreet et al., 2003)

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

point_mutation

3L:7,533,378..7,533,378 [+]

Nucleotide change:

C7533378T

Reported nucleotide change:

C?T

Amino acid change:

Reported amino acid change:

Q2term

(Overstreet et al., 2003)

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

lethal | recessive

(Cadavid et al., 2000, Fischer et al., 1997)

visible

(Fischer et al., 1997)

Phenotype Manifest In

dorsal vessel wall cell | increased number

(Tian et al., 2004)

retina

(Fischer et al., 1997)

Detailed Description

Statement

Reference

Homozygous embryos have an excess of cardioblasts.

(Tian et al., 2004)

Homozygotes exhibit rough eyes, retinal morphology is extremely disrupted.

(Fischer et al., 1997)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Phenotype Manifest In

Enhancer of

Statement

Reference

lqf^bE248 is an enhancer of phenotype of faf^BX3

(Fischer et al., 1997)

Additional Comments

Genetic Interactions

Statement

Reference

Enhances the faf^BX3 eye phenotype: eye is malformed with a rough exterior.

(Fischer et al., 1997)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

Comments

Allelic series based on viability: lqf^FDD9 < lqf^bE248 < lqf^S011027 < lqf^BT < lqf^ARI = lqf^L895 = lqf^L71.

(Overstreet et al., 2003)

Allelic series of phenotypic severity: lqf^ARI >= lqf^AG > lqf^bE25 > lqf^bE248 > lqf^S011027.

(Tian et al., 2004)

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (4)

Reported As

Symbol Synonym

E(faf)bE25^bE248

(Fischer et al., 1997)

bE428

(Overstreet et al., 2003)

lqf^bE248

lqf^be248

(Tian et al., 2004)

Name Synonyms

Secondary FlyBase IDs

References (4)

Report Sections

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