FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\AwhUAS.cCa
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General Information
Symbol
Dmel\AwhUAS.cCa
Species
D. melanogaster
Name
Saccharomyces cerevisiae UAS construct a of Curtiss
FlyBase ID
FBal0066277
Feature type
allele
Associated gene
Dmel\Awh
Associated Insertion(s)
Carried in Construct
P{UAS-Awh.C}
Key Links
Transgenic product class
cDNA
(Curtiss and Heilig, 1997)
wild_type
(Curtiss and Heilig, 1997)
Mutagen
Nature of the Allele
Transgenic product class
cDNA
(Curtiss and Heilig, 1997)
wild_type
(Curtiss and Heilig, 1997)
Mutagen
in vitro construct
(Curtiss and Heilig, 1997)
Progenitor genotype
Carried in construct
P{UAS-Awh.C}
Cytology
Description

An Awh cDNA is expressed under the control of UAS regulatory sequences.

(Curtiss and Heilig, 1997)
Allele components
Component
Use(s)
Regulatory region(s)
UAS
Encoded product / tool
Awh
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Mis-expression of AwhScer\UAS.cCa under the control of Scer\GAL4ey.PH reduces or abolishes the eye.

      Clones of cells mis-expressing Scer\GAL4αTub84B.PL>AwhScer\UAS.cCa in eye discs fail to differentiate as photoreceptors.

      (Roignant et al., 2010)

      Flies expressing AwhScer\UAS.cCa under the control of Scer\GAL4Bx-MS1096 survive to the adult stage. Their wings are reduced to stubs, but thoracic structures derived from the wing disc are normal. A small portion of the ventral part of the eye, the vibrissae and vertical bristles of the head are missing. The capitellum of the halteres and the internal genitalia are missing, and the coxa and femur of the legs are twisted and misshapen. The larval salivary glands are present in larvae expressing AwhScer\UAS.cCa under the control of Scer\GAL4Bx-MS1096. The larval photosensory organ and tracheal system develops normally in larvae expressing AwhScer\UAS.cCa under the control of Scer\GAL4Bx-MS1096. Larval wing and eye-antennal imaginal discs in which AwhScer\UAS.cCa is expressed under the control of Scer\GAL4Bx-MS1096 show excess programmed cell death, although the discs are normal in size and shape.

      (Curtiss and Heilig, 1997)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference

      The expression of AwhScer\UAS.cCa in clones of cells under the control of Scer\GAL4αTub84B.PL is unable to block photoreceptor differentiation when mis-expressed in Chi45F mutant cells.

      (Roignant et al., 2010)
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (3)
      Reported As
      Symbol Synonym
      AwhScer\UAS.cCa
      AwhUAS.cCa
      Name Synonyms
      Saccharomyces cerevisiae UAS construct a of Curtiss
      (Curtiss and Heilig, 1997)
      Secondary FlyBase IDs
        References (2)