FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\tldA.UAS.Tag:HA
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General Information
Symbol
Dmel\tldA.UAS.Tag:HA
Species
D. melanogaster
Name
FlyBase ID
FBal0082171
Feature type
allele
Associated gene
Dmel\tld
Associated Insertion(s)
Carried in Construct
P{UAS-tld.A.T:HA1}
Key Links
Transgenic product class
Mutagen
Nature of the Allele
Transgenic product class
Mutagen
in vitro construct
(Marques et al., 1997)
Progenitor genotype
Carried in construct
P{UAS-tld.A.T:HA1}
Cytology
Description

tld coding sequences lacking nucleotides 178 to 477 (the propeptide region) and tagged at the C-terminal end with three copies of the Tag:HA tag are expressed under the control of UASt regulatory sequences.

(Marques et al., 1997)
Allele components
Component
Use(s)
Regulatory region(s)
UASt
Encoded product / tool
tld
Tagged with
Tag:HA
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Expression of tldA.Scer\UAS.T:Ivir\HA1 in the posterior of the wing, driven by Scer\GAL4en-e16E, causes expansion of the posterior crossvein in 31/52 adult wings. In contrast, in 18/52 of these wings, the posterior crossvein is completely or partially missing.

      (Serpe et al., 2005)

      When tldA.Scer\UAS.T:Ivir\HA1 is driven by Scer\GAL4A9 some loss of wing margin bristles is seen but all veins form normally.

      (Shimmi and O'Connor, 2003)

      Produces a dominant wing phenotype when expressed using Scer\GAL4A9.

      (Marques et al., 1997)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference

      Coexpression of sogScer\UAS.cYa and tsgScer\UAS.cYa in the wing disc, under the control of Scer\GAL4A9, produces a small wing with altered patterns of venation. Coexpression of tldA.Scer\UAS.T:Ivir\HA1 with these two transgenes is able to reverse the small wing phenotype and restore normal patterning.

      (Serpe et al., 2005)

      The addition of tldA.Scer\UAS.T:Ivir\HA1 to sogScer\UAS.T:Ivir\HA1, tsgScer\UAS.T:Zzzz\His6, Scer\GAL4A9 animals suppresses the wing phenotypes seen in those animals.

      (Shimmi and O'Connor, 2003)
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (3)
      Reported As
      Symbol Synonym
      tldA.Scer\UAS.T:Ivir\HA1
      tldA.UAS.T:HA1
      tldA.UAS.Tag:HA
      Name Synonyms
      Secondary FlyBase IDs
        References (4)