FlyBase Allele Report: Dmel\apt[tdf-PΔ4]

General Information

Symbol

Dmel\apt^tdf-PΔ4

Species

D. melanogaster

Name

FlyBase ID

FBal0082191

Feature type

allele

Associated gene

Dmel\apt

Associated Insertion(s)

Carried in Construct

Also Known As

apt^PΔ4

Key Links

Allele class

Mutagen

P-element activity

Nature of the Allele

Allele class

Mutagen

P-element activity

(Eulenberg and Schuh, 1997)

Progenitor genotype

apt^tdf-C5-2-5

(Eulenberg and Schuh, 1997)

Cytology

Description

Deletion of a portion of the first exon and 5' flanking sequences.

(Eulenberg and Schuh, 1997)

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

chemical resistant | dominant

(McClure and Heberlein, 2013)

lethal | recessive

(Eulenberg and Schuh, 1997)

visible | somatic clone

(Wang et al., 2017)

Phenotype Manifest In

embryonic/larval tracheal section

(Eulenberg and Schuh, 1997)

wing | somatic clone

(Wang et al., 2017)

Detailed Description

Statement

Reference

apt^tdf-PΔ4 wing disc clones lead to formation of small adult wings with blisters, as compared to controls.

Adult wings of apt^tdf-PΔ4/+ mutants appear normal.

(Wang et al., 2017)

Heterozygous flies show a dramatic reduction in ethanol sedation sensitivity compared to wild type.

(McClure and Heberlein, 2013)

Stereotypic outgrowth of tracheal branches is severely disrupted in mutant embryos. Mutants show variable tracheal defects.

(Eulenberg and Schuh, 1997)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Other

Statement

Reference

apt^tdf-PΔ4/apt[+], hh² has visible phenotype

(Wang et al., 2017)

apt^tdf-PΔ4/apt[+], hh² has abnormal size | adult stage phenotype

(Wang et al., 2017)

Phenotype Manifest In

Other

Statement

Reference

apt^tdf-PΔ4/apt[+], hh² has wing phenotype

(Wang et al., 2017)

apt^tdf-PΔ4/apt[+], hh² has crossvein | ectopic phenotype

(Wang et al., 2017)

apt^tdf-PΔ4, bru1^QB has embryonic head phenotype

(Lie and Macdonald, 1999)

apt^tdf-PΔ4, bru1^QB, nanos^L7 has embryonic head phenotype

(Lie and Macdonald, 1999)

Additional Comments

Genetic Interactions

Statement

Reference

hh²/+, apt^tdf-PΔ4/+ double mutant adults exhibit smaller wings with an ectopic crossvein, as compared to controls.

(Wang et al., 2017)

Embryos derived from a cross of wild-type males to females heterozygous for aret^QB and also heterozygous for apt^tdf-PΔ4 occasionally have head defects (these defects are not seen in embryos derived from females singly heterozygous for aret^QB or apt^tdf-PΔ4). This phenotype is largely suppressed if the females are also heterozygous for nos^L7.

(Lie and Macdonald, 1999)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (3)

Reported As

Symbol Synonym

apt^PΔ4

(Wang et al., 2020, Shen et al., 2018, Wang et al., 2017, Liu et al., 2014, McClure and Heberlein, 2013, Lie and Macdonald, 1999)

apt^tdf-PΔ4

(Monahan and Starz-Gaiano, 2016)

tdf^PΔ4

Name Synonyms

Secondary FlyBase IDs

References (8)

Report Sections

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