FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\simunspecified
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General Information
Symbol
Dmel\simunspecified
Species
D. melanogaster
Name
FlyBase ID
FBal0086339
Feature type
allele
Associated gene
Dmel\sim
Associated Insertion(s)
Carried in Construct
Key Links
Allele class
Mutagen
    Nature of the Allele
    Allele class
    Mutagen
    Progenitor genotype
    Cytology
    Description

    FlyBase curator comment: this entry is used to capture phenotypic information when the particular allele (or allele combination) used by the author could not be determined but the context of the experiment suggests that the phenotype being described is some kind of loss of function.

    (FlyBase Curators, 2025-)
    Mutations Mapped to the Genome
    Curation Data
    Type
    Location
    Additional Notes
    References
    Variant Molecular Consequences
    Associated Sequence Data
    DDBJ / EMBL / GenBank
    DNA sequence
    Protein sequence
     
    UniProtKB/Swiss-Prot
      UniProtKB/TrEMBL
        Expression Data
        Reporter Expression
        Additional Information
        Statement
        Reference
         
        Marker for
        Reflects expression of
        Reporter construct used in assay
        Human Disease Associations
        Disease Ontology (DO) Annotations
        Models Based on Experimental Evidence ( 0 )
        Disease
        Evidence
        References
        Modifiers Based on Experimental Evidence ( 0 )
        Disease
        Interaction
        References
        Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
         
        Disease-implicated variant(s)
         
        Phenotypic Data
        Phenotypic Class
        Phenotype Manifest In
        Detailed Description
        Statement
        Reference

        Mutants show defects in the axon pattern of class IV dendritic arborization (da) neurons. The axon scaffold has fused longitudinals.

        (Grueber et al., 2007)

        In simunspecified stage 15 embryos, the genital disc precursor cells are completely missing.

        (Chen et al., 2005)

        The GMC-1 in mutants frequently (in about 9% of hemisegments) divide symmetrically to generate two RP2s instead of an RP2 and a sib.

        (Mehta and Bhat, 2001)

        All longitudinal axon tracts collapse onto the midline. No commissures are evident. All midline cells degenerate. Longitudinal connectives show frequent breaks.

        (Hummel et al., 1999)

        simunspecified mutant embryos have narrow denticle bands in all segments. The ventral arms of the head skeleton are fused, and the anal plates are fused. The transverse commissures are completely missing in the ventral nervous system. The mesectodermal cells are missing.

        (Tearle and Nusslein-Volhard, 1987)
        External Data
        Interactions
        Show genetic interaction network for Enhancers & Suppressors
        Phenotypic Class
        Phenotype Manifest In
        Enhanced by
        Suppressed by
        Additional Comments
        Genetic Interactions
        Statement
        Reference

        The penetrance of the GMC-1 phenotype in these embryos is enhanced to about 42% by the addition of Dp(2;2)GYL a duplication that includes nub and pdm2, and suppressed to about 1.4% by Df(2L)GR4 (whic deletes nub and pdm2).

        (Mehta and Bhat, 2001)
        Xenogenetic Interactions
        Statement
        Reference
        Complementation and Rescue Data
        Comments
        Images (0)
        Mutant
        Wild-type
        Stocks (0)
        Notes on Origin
        Discoverer
        External Crossreferences and Linkouts ( 0 )
        Synonyms and Secondary IDs (1)
        Reported As
        Symbol Synonym
        simunspecified
        Name Synonyms
        Secondary FlyBase IDs
          References (10)