FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\fus2
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General Information
Symbol
Dmel\fus2
Species
D. melanogaster
Name
FlyBase ID
FBal0086587
Feature type
allele
Associated gene
Dmel\fus
Associated Insertion(s)
P{lacW}fus2
Carried in Construct
Key Links
Genomic Maps

Allele class
Mutagen
Nature of the Allele
Allele class
Mutagen
P-element activity
(Wakabayashi-Ito and Anderson, 1998)
Delta2-3 transposase
(Wakabayashi-Ito et al., 2001)
Progenitor genotype
P{lacW}Vha36-1k07207
(Wakabayashi-Ito et al., 2001)
Associated Insertion(s)
P{lacW}fus2
Cytology
Description

Insertion of P{lacW} 100 nucleotides upstream of the 5' end of the class A cDNA sequence.

(Wakabayashi-Ito et al., 2001)
Allele components
Component
Use(s)
Inserted element
P{lacW}
Encoded product / tool
lacZ
Tagged with
Tag:NLS(P)
Mutations Mapped to the Genome
Curation Data
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Homozygotes show lethality at the end of embryogenesis with no clear defects in the larval cuticle.

      (Wakabayashi-Ito et al., 2001)

      fus mutant homozygotes die at the end of embryogenesis.

      (Wakabayashi-Ito and Anderson, 1998)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Enhanced by
      Statement
      Reference

      cactE10, fus[+]/fus2 has embryonic epidermis phenotype, enhanceable by Egfrfus

      (Wakabayashi-Ito et al., 2001)
      Enhancer of
      Statement
      Reference

      Egfr[+], fus[+], Egfrfus, fus2 is an enhancer of embryonic epidermis phenotype of cactE10

      (Wakabayashi-Ito et al., 2001)

      fus2 is an enhancer of embryonic epidermis phenotype of cactE10

      (Wakabayashi-Ito and Anderson, 1998)
      NOT Enhancer of
      Statement
      Reference

      fus[+]/fus2 is a non-enhancer of embryonic epidermis phenotype of cactE10

      (Wakabayashi-Ito et al., 2001)
      Additional Comments
      Genetic Interactions
      Statement
      Reference

      More than 80% of embryos produced by cactE10/+, fus1/+ are distinctly dorsalized, and the Egfrfus,fus2 chromosome has a similar but stronger effect.

      (Wakabayashi-Ito et al., 2001)

      cactE10/+; fus2/+ females lay 90% weakly dorsalized embryos.

      (Wakabayashi-Ito and Anderson, 1998)
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Fails to complement

      fus1

      (Wakabayashi-Ito et al., 2001)
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (1)
      Notes on Origin
      Discoverer

      Associated with: Egfrfus.

      (Wakabayashi-Ito et al., 2001)
      Comments
      Comments

      Mutation is unstable in the presence of transposase.

      (Wakabayashi-Ito et al., 2001)
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (1)
      Reported As
      Symbol Synonym
      fus2
      Name Synonyms
      Secondary FlyBase IDs
        References (2)