FlyBase Allele Report: Dmel\S[Kojak]

General Information

Symbol

Dmel\S^Kojak

Species

D. melanogaster

Name

FlyBase ID

FBal0086769

Feature type

allele

Associated gene

Dmel\S

Associated Insertion(s)

Carried in Construct

Key Links

Allele class

gain of function allele

Mutagen

ethyl methanesulfonate

Nature of the Allele

Allele class

gain of function allele

(Ruden et al., 1998)

Mutagen

ethyl methanesulfonate

(Ruden et al., 1999)

Progenitor genotype

Cytology

Description

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

female sterile | dominant

(Ruden et al., 1998)

female sterile soma-dependent | dominant

(Ruden et al., 1999)

visible | dominant

(Ruden et al., 1999)

Phenotype Manifest In

dorsocentral bristle

(Ruden et al., 1999)

egg chamber

(Ruden et al., 1999, Ruden et al., 1998)

interommatidial bristle

(Ruden et al., 1999)

macrochaeta

(Ruden et al., 1999)

nurse cell

(Ruden et al., 1999)

oocyte

(Ruden et al., 1999)

scutellar bristle

(Ruden et al., 1999)

Detailed Description

Statement

Reference

More than 99% of ovarioles from heterozygous females have egg chambers that develop with no obvious abnormalities until stage 10A. After this stage, the nurse cells fail to dump their contents into the oocyte, and the egg chambers deteriorate such that the nurse cells and oocyte form large vacuoles. 40-50% of interommatidial bristles are missing, and the remainder do not point in the same direction in heterozygous flies. The long bristles, such as the dorsocentral and scutellar bristles, are short and bent. Mosaic females that are heterozygous in the germline and have wild-type follicle cells can produce eggs. Clonal analysis indicates that S^Kojak exerts at least part of its soma-dependent dominant female sterile phenotype from the posterior pole follicle cells.

(Ruden et al., 1999)

Follicle-dependent female sterile mutation. Affects the formation of both the D-V and A-P axes of the egg chamber.

(Ruden et al., 1998)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Enhancer of

Statement

Reference

S^Kojak is an enhancer of visible phenotype of Ras85D^N17.sev

(Ruden et al., 1999)

S^Kojak is an enhancer of visible | recessive phenotype of Raf¹²

(Ruden et al., 1999)

Suppressor of

Statement

Reference

S^Kojak is a suppressor of visible | recessive phenotype of sev⁶

(Ruden et al., 1999)

Phenotype Manifest In

Enhancer of

Statement

Reference

S^Kojak is an enhancer of eye phenotype of Ras85D^N17.sev

(Ruden et al., 1999)

S^Kojak is an enhancer of photoreceptor cell R7 phenotype of Ras85D^N17.sev

(Ruden et al., 1999)

S^Kojak is an enhancer of eye phenotype of Raf¹²

(Ruden et al., 1999)

S^Kojak is an enhancer of photoreceptor cell R7 phenotype of Raf¹²

(Ruden et al., 1999)

Suppressor of

Statement

Reference

S^Kojak is a suppressor of photoreceptor cell R7 phenotype of sev⁶

(Ruden et al., 1999)

Additional Comments

Genetic Interactions

Statement

Reference

The R7 photoreceptors fail to develop in homozygous sev⁶ flies. This phenotype is partly suppressed by S^Kojak; sev⁶/sev⁶ ; S^Kojak/+ flies have an R7 cell in approximately 50% of the ommatidia. Enhances the small eye phenotype of hemizygous phl¹² flies. phl¹²/Y ; S^Kojak/+ flies have no R7 photoreceptor cells. The small eye phenotype of flies carrying Ras85D^N17.sev is enhanced by S^Kojak. Ras85D^N17.sev/S^Kojak flies have as many as 3 to 4 extra R7 photoreceptor cells in each ommatidium.

(Ruden et al., 1999)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Fails to complement

S¹

(Ruden et al., 1999)

Rescued by

S^Kojak is rescued by Scer\GAL4^CY2/S^UAS.cGa

(Ruden et al., 1999)

Comments

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

Comments

Etymology: the mutation is named "Kojak" after the bald television detective.

(Ruden et al., 1999)

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (2)

Reported As

Symbol Synonym

S^Kojak

Star^Kojak

(Ruden et al., 1999)

Name Synonyms

Secondary FlyBase IDs

References (3)

Report Sections

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