FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\Met128
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General Information
Symbol
Dmel\Met128
Species
D. melanogaster
Name
FlyBase ID
FBal0089547
Feature type
allele
Associated gene
Dmel\Met
Associated Insertion(s)
Carried in Construct
Key Links
Genomic Maps

Allele class
Mutagen
Nature of the Allele
Allele class
Mutagen
X ray
(Ashok et al., 1998)
Progenitor genotype
Cytology
Description

Amino acid replacement: R433G.

(Wilson et al., 2006)
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
point_mutation
X:11,618,233..11,618,233 [+]
Nucleotide change:

C11618233G

Amino acid change:

R433G | Met-PA; R433G | Met-PB

Reported amino acid change:

R433G

Comment:

Site of nucleotide substitution in mutant inferred by FlyBase based on reported amino acid change.

(Wilson et al., 2006)
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Homozygotes show increased resistance to methoprene compared to controls.

      Homozygous females have a reduced rate of oviposition compared to controls.

      20% of mutant flies have a small number of defective ommatidia in the posterior quarter of the eye.

      (Wilson et al., 2006)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Other
      Phenotype Manifest In
      Enhancer of
      Statement
      Reference

      Met128/Met128 is an enhancer of ovary phenotype of br1

      (Wilson et al., 2006)
      Additional Comments
      Genetic Interactions
      Statement
      Reference

      br1, Rst(1)JH128 double mutant escapers show significantly reduced levels of oogenesis compared to br1 single mutants.

      (Wilson et al., 2006)
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (1)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (2)
      Reported As
      Symbol Synonym
      Met128
      (Wilson et al., 2006, Wilson et al., 2006, Flatt and Kawecki, 2004)
      Rst(1)JH128
      Name Synonyms
      Secondary FlyBase IDs
        References (4)