FlyBase Allele Report: Dmel\bcd[p2107]

General Information

Symbol

Dmel\bcd^p2107

Species

D. melanogaster

Name

FlyBase ID

FBal0090466

Feature type

allele

Associated gene

Dmel\bcd

Associated Insertion(s)

Carried in Construct

P{bcd+lacZ}

Key Links

Transgenic product class

genomic_DNA

(Ruez et al., 1998)

wild_type

(Ruez et al., 1998)

Mutagen

in vitro construct

Nature of the Allele

Transgenic product class

genomic_DNA

(Ruez et al., 1998)

wild_type

(Ruez et al., 1998)

Mutagen

in vitro construct

(Ruez et al., 1998, MacDonald et al., 1993)

Progenitor genotype

Carried in construct

P{bcd+lacZ}

Cytology

Description

Contains a 7.5kb bcd genomic fragment (from -2725bp to +4594bp relative to the transcription start site) which contains the entire bcd coding region and 3' UTR, with a 1.3kb fragment of the Ecol\lacZ gene (used as an RNA tag) inserted in the bcd 3' UTR.

(Ruez et al., 1998)

A 1.3kb Ecol\lacZ gene fragment is inserted close to the polyadenylation site of wild-type bcd.

(MacDonald et al., 1993)

Allele components

Component

Use(s)

Regulatory region(s)

bcd

Encoded product / tool

bcd

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

distribution deduced from reporter

Stage

Tissue/Position (including subcellular localization)

Reference

embryonic stage 2

organism | 10-20% egg length

(MacDonald et al., 1993)

oogenesis stage S5 -- S6 & adult stage | female

oocyte | anterior

(MacDonald et al., 1993)

oogenesis stage S9 & adult stage | female

oocyte | anterior

(MacDonald et al., 1993)

oogenesis stage S10 -- S11 & adult stage | female

oocyte | anterior

(MacDonald et al., 1993)

Additional Information

Statement

Reference

The bcd^T:EcollacZtranscript is localized and accumulates at the anterior cortex of the oocytevery early on during oogenesis. As oogenesis proceeds, the transcript continuesto accumulate and little or no diffusion of signal is observed. In the earlyembryo the transcript remains localized anteriorly, reaching up to 20% egglength.

(MacDonald et al., 1993)

Marker for

Reflects expression of

bcd

(MacDonald et al., 1993)

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

wild-type

(Ruez et al., 1998)

Phenotype Manifest In

Detailed Description

Statement

Reference

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Phenotype Manifest In

NOT Suppressor of

Statement

Reference

bcd^p2107 is a non-suppressor of phenotype of Sry-δ^SF2

(Ruez et al., 1998)

Additional Comments

Genetic Interactions

Statement

Reference

Eggs laid by homozygous Sry-δ^SF2 escaper females develop into embryos which have cuticles with a strong bcd-like phenotype, showing deletion of anterior structures and thoracic segments and duplication of the posterior telson. This phenotype is not significantly altered by bcd^T:Ecol\lacZ.

(Ruez et al., 1998)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Rescues

bcd^p2107 rescues bcd⁸

(Ruez et al., 1998)

Comments

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (3)

Reported As

Symbol Synonym

bcd^T:Ecol\lacZ

bcd^T:lacZ

bcd^p2107

Name Synonyms

Secondary FlyBase IDs

References (3)

Report Sections

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