FlyBase Allele Report: Dmel\Sry-δ[SF2]

General Information

Symbol

Dmel\Sry-δ^SF2

Species

D. melanogaster

Name

FlyBase ID

FBal0016089

Feature type

allele

Associated gene

Dmel\Sry-δ

Associated Insertion(s)

Carried in Construct

Key Links

Genomic Maps

JBrowse

Allele class

Mutagen

ethyl methanesulfonate

Nature of the Allele

Allele class

Mutagen

ethyl methanesulfonate

(Payre et al., 1994, Crozatier et al., 1992)

Progenitor genotype

Cytology

Description

Nucleotide substitution: C787T. Amino acid replacement: R263C. This is within the third zinc finger.

(Crozatier et al., 1992)

sequenced by Crozatier et al., 1992

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

point_mutation

3R:30,044,262..30,044,262 [+]

Nucleotide change:

C30044262T

Reported nucleotide change:

C787T

Amino acid change:

R262C | Sry-delta-PA

Reported amino acid change:

R263C

Comment:

From GB:X76235

(Crozatier et al., 1992)

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

lethal | recessive

(Ferrer et al., 1994, Payre et al., 1994)

partially lethal

(Crozatier et al., 1992)

Phenotype Manifest In

embryonic/first instar larval cuticle

(Ruez et al., 1998)

embryonic/first instar larval cuticle & thoracic segment

(Ruez et al., 1998)

gonad | male

(Crozatier et al., 1992)

spermatozoon

(Crozatier et al., 1992)

telson | posterior

(Ruez et al., 1998)

Detailed Description

Statement

Reference

Sry-δ^SF2 homozygous females have normal ovaries.

(Smulders-Srinivasan and Lin, 2003)

Eggs laid by homozygous escaper females develop into embryos which have cuticles with a strong bcd-like phenotype, showing deletion of anterior structures and thoracic segments and duplication of the posterior telson.

(Ruez et al., 1998)

Approximately 60-70% of hemizygous embryos survive. Approximately 80% of hemizygous males survive to adulthood. These males show a pronounced atrophy of the gonads, with no spermatozoa bundles. Female hemizygous escapers do not lay any eggs.

(Crozatier et al., 1992)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Suppressed by

Statement

Reference

Sry-δ^SF2 has lethal phenotype, suppressible by Dpse\Sry-delta^tFa

(Ferrer et al., 1994)

Other

Statement

Reference

Dpse\Sry-delta^tFa, Sry-δ^SF2 has viable phenotype

(Ferrer et al., 1994)

Phenotype Manifest In

Suppressed by

Statement

Reference

Sry-δ^SF2 has embryonic/first instar larval cuticle phenotype, suppressible by bcd^p2107sbcs

(Ruez et al., 1998)

Sry-δ^SF2 has embryonic/first instar larval cuticle & thoracic segment phenotype, suppressible by bcd^p2107sbcs

(Ruez et al., 1998)

Sry-δ^SF2 has telson | posterior phenotype, suppressible by bcd^p2107sbcs

(Ruez et al., 1998)

NOT suppressed by

Statement

Reference

Sry-δ^SF2 has phenotype, non-suppressible by bcd^p2107

(Ruez et al., 1998)

Suppressor of

Statement

Reference

Sry-δ^SF2/Sry-delta[+] is a suppressor of female germline stem cell phenotype of piwi²

(Smulders-Srinivasan and Lin, 2003)

Additional Comments

Genetic Interactions

Statement

Reference

The Sry-δ^SF2 phenotype is not significantly altered by bcd^T:Ecol\lacZ, but is rescued by bcd^{sbcs.T:Ecol\lacZ}.

(Ruez et al., 1998)

Xenogenetic Interactions

Statement

Reference

Lethality is completely rescued by one copy of Dpse\Sry-δ^tFa.

(Ferrer et al., 1994)

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

Comments

Introduction of P{sryDB56,ry⁺} causes partial rescue of the mutant phenotype, thoracic segments are missing and elements of telson are duplicated.

(Payre et al., 1994)

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (3)

Reported As

Symbol Synonym

Sry δ^SF2

(Ruez et al., 1998)

Sry-δ^SF2

(Dong et al., 2020)

δSF2

(Ferrer et al., 1994)

Name Synonyms

Secondary FlyBase IDs

References (6)

Report Sections

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