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General Information
Symbol
Dmel\Sry-δSF2
Species
D. melanogaster
Name
FlyBase ID
FBal0016089
Feature type
allele
Associated gene
Associated Insertion(s)
Carried in Construct
Key Links
Allele class
Nature of the Allele
Allele class
Mutations Mapped to the Genome
 
Type
Location
Additional Notes
References
Nucleotide change:

C30044262T

Reported nucleotide change:

C787T

Amino acid change:

R262C | Sry-delta-PA

Reported amino acid change:

R263C

Comment:
Associated Sequence Data
DNA sequence
Protein sequence
 
 
Progenitor genotype
Cytology
Nature of the lesion
Statement
Reference

Nucleotide substitution: C787T. Amino acid replacement: R263C. This is within the third zinc finger.

sequenced by Crozatier et al., 1992

Expression Data
Reporter Expression
Additional Information
Statement
Reference
 
Marker for
Reflects expression of
Reporter construct used in assay
Human Disease Associations
Disease Ontology (DO) Annotations
Models Based on Experimental Evidence ( 0 )
Disease
Evidence
References
Modifiers Based on Experimental Evidence ( 0 )
Disease
Interaction
References
Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
 
Disease-implicated variant(s)
 
Phenotypic Data
Phenotypic Class
Phenotype Manifest In
Detailed Description
Statement
Reference

Sry-δSF2 homozygous females have normal ovaries.

Eggs laid by homozygous escaper females develop into embryos which have cuticles with a strong bcd-like phenotype, showing deletion of anterior structures and thoracic segments and duplication of the posterior telson.

Approximately 60-70% of hemizygous embryos survive. Approximately 80% of hemizygous males survive to adulthood. These males show a pronounced atrophy of the gonads, with no spermatozoa bundles. Female hemizygous escapers do not lay any eggs.

External Data
Interactions
Show genetic interaction network for Enhancers & Suppressors
Phenotypic Class
Suppressed by
Statement
Reference

Sry-δSF2 has lethal phenotype, suppressible by Dpse\Sry-deltatFa

Other
Statement
Reference
Phenotype Manifest In
Suppressed by
Statement
Reference

Sry-δSF2 has embryonic/first instar larval cuticle & thoracic segment phenotype, suppressible by bcdp2107sbcs

Sry-δSF2 has telson | posterior phenotype, suppressible by bcdp2107sbcs

NOT suppressed by
Statement
Reference

Sry-δSF2 has phenotype, non-suppressible by bcdp2107

Suppressor of
Statement
Reference
Additional Comments
Genetic Interactions
Statement
Reference

The Sry-δSF2 phenotype is not significantly altered by bcdT:Ecol\lacZ, but is rescued by bcdsbcs.T:Ecol\lacZ.

Xenogenetic Interactions
Statement
Reference

Lethality is completely rescued by one copy of Dpse\Sry-δtFa.

Complementation and Rescue Data
Comments
Images (0)
Mutant
Wild-type
Stocks (0)
Notes on Origin
Discoverer
Comments
Comments

Introduction of P{sryDB56,ry+} causes partial rescue of the mutant phenotype, thoracic segments are missing and elements of telson are duplicated.

External Crossreferences and Linkouts ( 0 )
Synonyms and Secondary IDs (3)
Reported As
Symbol Synonym
Name Synonyms
Secondary FlyBase IDs
    References (6)