FlyBase Allele Report: Dmel\amn[hs.PM]

General Information

Symbol

Dmel\amn^hs.PM

Species

D. melanogaster

Name

heat shock construct of Moore

FlyBase ID

FBal0090483

Feature type

allele

Associated gene

Dmel\amn

Associated Insertion(s)

Carried in Construct

P{hs-amn.M}

Key Links

Transgenic product class

genomic_DNA

(Moore et al., 1998)

wild_type

(Moore et al., 1998)

Mutagen

in vitro construct

Nature of the Allele

Transgenic product class

genomic_DNA

(Moore et al., 1998)

wild_type

(Moore et al., 1998)

Mutagen

in vitro construct

(Moore et al., 1998)

Progenitor genotype

Carried in construct

P{hs-amn.M}

Cytology

Description

A 744bp genomic fragment containing the amn open reading frame is expressed under the control of an Hsp70 promoter.

(Moore et al., 1998)

Allele components

Component

Use(s)

Regulatory region(s)

Hsp70

Encoded product / tool

amn

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

wild-type

(Yager et al., 2001, Moore et al., 1998)

Phenotype Manifest In

Detailed Description

Statement

Reference

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Phenotype Manifest In

Additional Comments

Genetic Interactions

Statement

Reference

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Rescues

amn^hs.PM rescues amn^X8

(Bhattacharya et al., 2004)

amn^hs.PM rescues amn^X8

(Yager et al., 2001)

amn^hs.PM rescues amn^X8

(Moore et al., 1998)

amn^hs.PM rescues amn^chpd

(Moore et al., 1998)

Partially rescues

amn^hs.PM partially rescues amn^X8

(DeZazzo et al., 1999)

Comments

The reduction in the L-type Ca²⁺ current seen in the muscles of third instar amn^X8 mutant larvae is rescued by expression of amn^hs.PM using heat shock.

(Bhattacharya et al., 2004)

Addition of amn^hs.PM to amn^X8 animals significantly rescues the perineurial glial thickness phenotype.

(Yager et al., 2001)

Heat shock induction in adults, such as is sufficient to rescue the ethanol sensitivity of amn^X8, cannot rescue the memory defects. Two alternative heat shock regimes in the adult also fail to rescue the memory defects of amn^X8.

(DeZazzo et al., 1999)

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (2)

Reported As

Symbol Synonym

amn^hs.PM

Name Synonyms

heat shock construct of Moore

(Moore et al., 1998)

Secondary FlyBase IDs

References (4)

Report Sections

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