FlyBase Allele Report: Dmel\gbb[D8]

General Information

Symbol

Dmel\gbb^D8

Species

D. melanogaster

Name

FlyBase ID

FBal0090531

Feature type

allele

Associated gene

Dmel\gbb

Associated Insertion(s)

Carried in Construct

Key Links

Genomic Maps

JBrowse

Allele class

Mutagen

ethyl nitrosourea

Nature of the Allele

Allele class

Mutagen

ethyl nitrosourea

(Chen et al., 1998)

Progenitor genotype

Cytology

Description

The premature stop codon falls in the prodomain.

(Chen et al., 1998)

Amino acid replacement: W179term.

(Chen et al., 1998)

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

point_mutation

2R:23,852,290..23,852,290 [+]

Nucleotide change:

G23852290A

Amino acid change:

W179term | gbb-PA; W179term | gbb-PB

Reported amino acid change:

W179term

Comment:

G to A nucleotide change at the second or third position of the wild type Trp codon leads to a nonsense mutation (exact site of mutation unspecified). The mutation was annotated at the second base of the codon.

(Chen et al., 1998)

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

Phenotype Manifest In

embryonic/larval fat body

(Chen et al., 1998)

embryonic midgut constriction 1

(Chen et al., 1998)

gastric caecum

(Chen et al., 1998)

larva

(Chen et al., 1998)

Detailed Description

Statement

Reference

gbb^D4/gbb^D8 larvae have a greatly reduced fat body and appear transparent. The gastric caecae are reduced in length in approximately 50% of larvae. The larvae grow more slowly than wild-type and are somewhat reduced in size. gbb^D4/gbb^D8 embryos fail to form the first midgut constriction, but the second and third constrictions form.

(Chen et al., 1998)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Other

Statement

Reference

gbb^D8, tkv⁶ has visible | dominant phenotype

(Chen et al., 1998)

gbb^D8, tkv⁶ has visible | recessive phenotype

(Chen et al., 1998)

gbb^D8/gbb^D4, tkv⁶ has lethal | recessive | embryonic stage phenotype

(Chen et al., 1998)

gbb^D8, tkv⁶ has lethal | recessive | embryonic stage phenotype

(Chen et al., 1998)

gbb^D8, put¹³⁵ has visible | dominant phenotype

(Chen et al., 1998)

dpp^s5, gbb^D8 has visible | dominant phenotype

(Chen et al., 1998)

Df(2L)tkv2, gbb^D8 has visible | dominant phenotype

(Chen et al., 1998)

gbb^D8, shn¹ has visible | dominant phenotype

(Chen et al., 1998)

Phenotype Manifest In

Enhanced by

Statement

Reference

gbb^D8/gbb^D4 has embryonic midgut constriction phenotype, enhanceable by tkv⁶

(Chen et al., 1998)

Other

Statement

Reference

gbb^D8, tkv⁶ has scutum phenotype

(Chen et al., 1998)

gbb^D8/gbb^D4, tkv⁶ has embryo phenotype

(Chen et al., 1998)

gbb^D8/gbb^D4, tkv⁶ has embryonic/first instar larval cuticle phenotype

(Chen et al., 1998)

gbb^D8/gbb^D4, tkv⁶ has embryonic head phenotype

(Chen et al., 1998)

gbb^D8, tkv⁶ has leg phenotype

(Chen et al., 1998)

Additional Comments

Genetic Interactions

Statement

Reference

gbb^D8 dominantly enhances the tkv⁶ phenotype; tkv⁶ homozygotes have a normal notum and legs, but the presence of one copy of gbb^D8 results in defects in the notum and legs. Double heterozygotes with Df(2L)tkv2, dpp^s5, shn¹ or put¹³⁵ may show imaginal disc development defects. No interaction with sax⁵, Mad^P1 or Med⁴ is seen in double heterozygous flies. tkv⁶ gbb^D4/tkv⁶ gbb^D8 embryos form only one midgut constriction. gbb^D4/tkv⁶ gbb^D8 embryos have head defects and an excessive ventral curvature. gbb^D4/tkv⁶ gbb^D8 embryos derived from homozygous tkv⁶ females have a dorsal open phenotype.

(Chen et al., 1998)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

Selected as: Dominant enhancer of the tkv⁶ phenotype. Induced on: tkv⁶.

(Chen et al., 1998)

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (3)

Reported As

Symbol Synonym

(Chen et al., 1998)

Tgfβ-60A^D8

gbb^D8

Name Synonyms

Secondary FlyBase IDs

References (1)

Report Sections

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