FlyBase Allele Report: Dmel\dco[L]

General Information

Symbol

Dmel\dco^L

Species

D. melanogaster

Name

Long

FlyBase ID

FBal0091524

Feature type

allele

Associated gene

Dmel\dco

Associated Insertion(s)

Carried in Construct

Also Known As

dbt^L

Key Links

Genomic Maps

JBrowse

Allele class

Mutagen

ethyl methanesulfonate

Nature of the Allele

Allele class

Mutagen

ethyl methanesulfonate

(Price et al., 1998)

Progenitor genotype

Cytology

Description

Amino acid replacement: M80I. M80 falls in a highly conserved region.

(Kloss et al., 1998)

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

point_mutation

3R:31,057,612..31,057,612 [-]

Nucleotide change:

G31057612H

Amino acid change:

Reported amino acid change:

M80I

Comment:

Site of nucleotide substitution in mutant inferred by FlyBase based on reported amino acid change.

(Kloss et al., 1998)

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

Phenotype Manifest In

Detailed Description

Statement

Reference

dco^L/+ flies have a lengthened circadian period.

(Huang et al., 2014)

In constant darkness, a small percentage of dco^EY02910/dco^L flies are arrhythmic and have a slightly longer period compared to wild type.

(Zheng et al., 2014)

dco^L flies have a long locomotion period compared to wild type. The locomotion period length of dco^L flies shows an improvement towards wild-type at higher temperatures, indicating a defect in temperature compensation. The transition point of the phase response curve in dco^L flies is very close to wild type, at about ZT 18.5.

(Rothenfluh et al., 2000)

Mutants require a higher dose than wild-type to induce behavioural responses to cocaine exposure and do not show significant sensitization to a second exposure.

(Andretic et al., 1999)

Heterozygotes produce locomotor rhythms with an average period of 24.9 hr in DD conditions. Homozygotes produce locomotor rhythms with an average period of 26.8 hr in DD conditions. Flies can be entrained by an LD 12:12 cycle. Mutant phenotype is completely penetrant. The period of the eclosion rhythm is longer than wild type.

(Price et al., 1998)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Other

Statement

Reference

Scer\GAL4^P2.4.Pdf, dco^L, lark^UAS.Tag:HA has abnormal locomotor rhythm phenotype

(Huang et al., 2014)

Scer\GAL4^P2.4.Pdf, dco^L, lark^RNAi.UAS.cSb has abnormal locomotor rhythm phenotype

(Huang et al., 2014)

Phenotype Manifest In

Additional Comments

Genetic Interactions

Statement

Reference

Adult-specific expression (using TubGAL80ts) of lark^{Scer\UAS.T:Ivir\HA1} driven by Scer\GAL4^P2.4.Pdf significantly lengthens circadian period in dco^L/+ flies; co-expression of lark^{dsRNA.Scer\UAS.cSb} significantly shortens circadian period.

(Huang et al., 2014)

Expression of one copy of wdb^EP3559 under the control of Scer\GAL4^tim.PE in a dco^L background lengthens the period of locomotor activity rhythms from 24.7 to 26 hours.

(Sathyanarayanan et al., 2004)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Fails to complement

dco^j3B9

(Price et al., 1998)

Comments

Images (0)

Mutant

Wild-type

Stocks (1)

Bloomington

80978

w^*; dco^L/TM3, Sb¹

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (3)

Reported As

Symbol Synonym

dbt^L

(Wang et al., 2022, Top et al., 2018, Huang et al., 2014, Zheng et al., 2014, Kivimäe et al., 2008, Preuss et al., 2004, Sathyanarayanan et al., 2004, Stanewsky, 2003, Stanewsky, 2002, Rothenfluh et al., 2000, Andretic et al., 1999, Subramanian and Lakhotia, 1999, Tyson et al., 1999, Hardin, 1998, Kloss et al., 1998, Price et al., 1998, Wilsbacher and Takahashi, 1998)

dco^L

(Titus et al., 2023)

Name Synonyms

Long

(Price et al., 1998)

Secondary FlyBase IDs

References (18)

Report Sections

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