FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Adeno5\E1amut.hp.IRES.NRE+.GMR
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General Information
Symbol
Adeno5\E1amut.hp.IRES.NRE+.GMR
Species
H. Human adenovirus type 5
Name
FlyBase ID
FBal0091902
Feature type
allele
Associated gene
Adeno5\E1a
Associated Insertion(s)
Carried in Construct
P{GMR-hp-IRES-E1Amut-NRE+}
Transgenic product class
Mutagen
Nature of the Allele
Transgenic product class
Mutagen
in vitro construct
(Wharton et al., 1998)
Progenitor genotype
Carried in construct
P{GMR-hp-IRES-E1Amut-NRE+}
Cytology
Description

A mutant form of Adeno5\E1a, with a sequence that forms a large hairpin in the 5'UTR (a head-to-head dimer of a 63bp fragment from the pBluescript polylinker) and a Ubx IRES (internal ribosome entry site) sequence inserted between the stem of the hairpin and the Adeno5\E1a coding region is expressed under the control of GMR regulatory sequences. A portion of the hb 3' UTR, with wild-type nos response elements (NREs) is fused downstream of the Adeno5\E1a coding region.

(Wharton et al., 1998)
Allele components
Component
Use(s)
Regulatory region(s)
GMR
Encoded product / tool
Adeno5\E1a
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Flies carrying Adeno5\E1ahp.GMR have defects in eye development.

      (Wharton et al., 1998)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Suppressed by
      Statement
      Reference

      Adeno5\E1amut.hp.IRES.NRE+.GMR has visible phenotype, suppressible by nanosGMR.PW

      (Wharton et al., 1998)
      Phenotype Manifest In
      Suppressed by
      Statement
      Reference

      Adeno5\E1amut.hp.IRES.NRE+.GMR has eye phenotype, suppressible by nanosGMR.PW

      (Wharton et al., 1998)
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference

      The Adeno5\E1amut.hp.IRES.NRE+.GMR eye phenotype is partially suppressed by nosGMR.PW.

      (Wharton et al., 1998)
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (1)
      Reported As
      Symbol Synonym
      Adeno5\E1amut.hp.IRES.NRE+.GMR
      Name Synonyms
      Secondary FlyBase IDs
        References (1)