FlyBase Allele Report: Dmel\E(spl)m8-HLH[K1K2mut]

General Information

Symbol

Dmel\E(spl)m8-HLH^K1K2mut

Species

D. melanogaster

Name

FlyBase ID

FBal0093418

Feature type

allele

Associated gene

Dmel\E(spl)m8-HLH

Associated Insertion(s)

Carried in Construct

P{E(spl)m8-HLH^K1K2mut}

Key Links

Transgenic product class

Mutagen

in vitro construct

Nature of the Allele

Transgenic product class

Mutagen

in vitro construct

(Lai et al., 1998)

Progenitor genotype

E(spl)m8-HLH^tLa

(Lai et al., 1998)

Carried in construct

P{E(spl)m8-HLH^K1K2mut}

Cytology

Description

Construct: The wild-type E(spl) 3' UTR has been replaced with a mutated E(spl) 3' UTR with a cluster of point mutations in the two K boxes.

(Lai et al., 1998)

Allele components

Component

Use(s)

Encoded product / tool

E(spl)m8-HLH

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

visible

(Lai et al., 1998)

Phenotype Manifest In

anterior orbital bristle

(Lai et al., 1998)

(Lai et al., 1998)

(Lai et al., 1998)

(Lai et al., 1998)

(Lai et al., 1998)

Detailed Description

Statement

Reference

Flies carrying two copies of E(spl)^K1K2mut in a wild-type background show peripheral nervous system and/or venation defects. These defects include loss of anterior orbital, postvertical and scutellar macrochaetae, loss of interocellar microchaetae and extra or missing crossvein material.

(Lai et al., 1998)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Enhancer of

Statement

Reference

E(spl)m8-HLH^K1K2mut is an enhancer of visible | dominant phenotype of N^spl-1

(Lai et al., 1998)

E(spl)m8-HLH^K1K2mut is an enhancer of visible | dominant phenotype of H^E31

(Lai et al., 1998)

Phenotype Manifest In

Enhancer of

Statement

Reference

E(spl)m8-HLH^K1K2mut is an enhancer of interommatidial bristle | ectopic phenotype of N^spl-1

(Lai et al., 1998)

E(spl)m8-HLH^K1K2mut is an enhancer of ommatidium phenotype of N^spl-1

(Lai et al., 1998)

E(spl)m8-HLH^K1K2mut is an enhancer of sense organ | adult stage phenotype of H^E31

(Lai et al., 1998)

Additional Comments

Genetic Interactions

Statement

Reference

Dominantly enhances the phenotype of H^E31/+ flies, resulting in a 40% reduction in head macrochaetae. Dominantly enhances the phenotype of N^spl-1/+ flies, resulting in ommatidial fusion and bristle multiplication in the eye.

(Lai et al., 1998)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (2)

Reported As

Symbol Synonym

E(spl)^K1K2mut

E(spl)m8-HLH^K1K2mut

Name Synonyms

Secondary FlyBase IDs

References (1)

Report Sections

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