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General Information
Symbol
Dmel\Su(H)VP16.UAS.Tag:MYC
Species
D. melanogaster
Name
FlyBase ID
FBal0095584
Feature type
allele
Associated gene
Associated Insertion(s)
Carried in Construct
Also Known As
UAS-Su(H)-VP16, UAS-Su(H)VP16
Key Links
Allele class
Nature of the Allele
Allele class
Mutations Mapped to the Genome
 
Type
Location
Additional Notes
References
Associated Sequence Data
DNA sequence
Protein sequence
 
 
Progenitor genotype
Carried in construct
Cytology
Nature of the lesion
Statement
Reference

Tag:MYC is fused to amino acid 10 of Su(H) coding region, which is then fused at its carboxy-terminus to amino acids 19-105 of Hsim\VP16. Expression of the construct is governed by UASt regulatory sequences.

Allele components
Product class / Tool use(s)
Encoded product / tool
Expression Data
Reporter Expression
Additional Information
Statement
Reference
 
Marker for
Reflects expression of
Reporter construct used in assay
Human Disease Associations
Disease Ontology (DO) Annotations
Models Based on Experimental Evidence ( 0 )
Disease
Evidence
References
Modifiers Based on Experimental Evidence ( 0 )
Disease
Interaction
References
Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
 
Disease-implicated variant(s)
 
Phenotypic Data
Phenotypic Class
Phenotype Manifest In
Detailed Description
Statement
Reference

The expression of Su(H)Scer\UAS.T:Hsap\MYC,T:Hsim\VP16 under the control of Scer\GAL4lz-gal4 leads to significant increases in both the number and size of third instar larval circulating crystal cells, as compared to controls.

Stage 13 embryos expressing Su(H)Scer\UAS.T:Hsap\MYC,T:Hsim\VP16 under the control of Scer\GAL4sim.P3.7 have approximately 16 anterior midline glia (AMG) compared to six in wild type. By stage 16 the number of AMG has reduced to 7, compared to three in wild type.

When Su(H)Scer\UAS.T:Hsap\MYC,T:Hsim\VP16 is driven by Scer\GAL4how-24B in the mesoderm differentiation of the visceral mesoderm is disrupted.

When expression is driven by Scer\GAL4dpp.blk1 adult wings show ectopic margin structures, similar to those induced by 'intra' forms of N.

External Data
Interactions
Show genetic interaction network for Enhancers & Suppressors
Phenotypic Class
Suppressor of
NOT Suppressor of
Statement
Reference
Phenotype Manifest In
Suppressor of
Statement
Reference
NOT Suppressor of
Statement
Reference
Additional Comments
Genetic Interactions
Statement
Reference

Expression of Su(H)Scer\UAS.T:Hsap\MYC,T:Hsim\VP16 in glia under the control of Scer\GAL4repo-M1B suppresses the Nl1N-ts1 longitudinal pioneer axon phenotype.

Expression of Su(H)Scer\UAS.T:Hsap\MYC,T:Hsim\VP16 in the pioneer neurons under the control of Scer\GAL415J2 fails to suppress the Nl1N-ts1 longitudinal pioneer axon phenotype.

Xenogenetic Interactions
Statement
Reference
Complementation and Rescue Data
Comments
Images (0)
Mutant
Wild-type
Stocks (0)
Notes on Origin
Discoverer
External Crossreferences and Linkouts ( 0 )
Synonyms and Secondary IDs (5)
Reported As
Symbol Synonym
Su(H)Scer\UAS.T:Hsap\MYC,T:Hsim\VP16
Su(H)UAS.T:Myc,T:VP16
Su(H)VP16.UAS.Tag:MYC
myc-Su(H)-VP16
Name Synonyms
Secondary FlyBase IDs
    References (13)