FlyBase Allele Report: Dmel\BubR1[unspecified]

General Information

Symbol

Dmel\BubR1^unspecified

Species

D. melanogaster

Name

FlyBase ID

FBal0095840

Feature type

allele

Associated gene

Dmel\BubR1

Associated Insertion(s)

Carried in Construct

Key Links

Allele class

Mutagen

Nature of the Allele

Allele class

Mutagen

Progenitor genotype

Cytology

Description

FlyBase curator comment: this entry is used to capture phenotypic information when the particular allele (or allele combination) used by the author could not be determined but the context of the experiment suggests that the phenotype being described is some kind of loss of function.

(FlyBase Curators, 2025-)

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

abnormal meiotic cell cycle | recessive

(Basu et al., 1999)

abnormal mitotic cell cycle

(Royou et al., 2005, Basu et al., 1998)

Phenotype Manifest In

meiotic cell cycle | male

(Basu et al., 1999)

mitosis & nuclear chromosome

(Basu et al., 1998)

mitotic anaphase

(Basu et al., 1998)

mitotic cell cycle

(Basu et al., 1998)

onion stage spermatid

(Basu et al., 1999)

onion stage spermatid & nucleus

(Basu et al., 1999)

Detailed Description

Statement

Reference

The mitotic index of mutant brains is significantly lower than seen in wild-type. A dose dependant reduction of mitotic index is seen in response to X rays.

(Royou et al., 2005)

Homozygous larval testes are significantly smaller than wild-type testes. Meiotic figures with severe spindle abnormalities at metaphase and anaphase are seen, as well as multiple nuclei of variable volume at telophase. Onion stage spermatids contain abnormal numbers of nuclei of variable size (including micronuclei) associated with a single Nebenkern of normal size.

(Basu et al., 1999)

Mutants have a lowered mitotic index, precocious sister chromatid separation, an increased frequency of anaphases and abnormal anaphases with lagging chromosomes and chromatid bridging.

(Basu et al., 1998)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Enhanced by

Statement

Reference

BubR1^unspecified has abnormal mitotic cell cycle phenotype, enhanceable by Crei\I-CreI^hs.PR

(Royou et al., 2005)

NOT Enhancer of

Statement

Reference

BubR1^unspecified is a non-enhancer of abnormal mitotic cell cycle phenotype of Crei\I-CreI^hs.PR

(Royou et al., 2005)

Phenotype Manifest In

Additional Comments

Genetic Interactions

Statement

Reference

grp^unspecified, BubR1^unspecified double mutants exhibit a mitotic index similar to BubR1^unspecified when not irradiated, but do not exhibit as great a X ray dose dependent reduction in mitotic index as seen in BubR1^unspecified.

grp^unspecified, Bub1^unspecified double mutants exhibit a mitotic index similar to Bub1^unspecified when not irradiated, but do not exhibit as great a X ray dose dependant reduction in mitotic index as seen in Bub1^unspecified.

(Royou et al., 2005)

Examination of the larval stage central nervous system of Bub1^unspecified Cdc27^L7123 double mutant shows cells arrested at metaphase at a comparable frequency to the Cdc27^L7123 mutant alone. Moreover, the high frequency of anaphases seen in the Bub1^unspecified mutant as a result of the malfunctioning checkpoint is replaced in the double mutant by an elevated frequency of metaphase-like figures typical of Cdc27^L7123. The appearance of mitotic figures in squashed preparations of Bub1^unspecified Cdc27^L7123 is indistinguishable from those seen in Cdc27^L7123 alone.

Examination of the larval stage central nervous system of BubR1^unspecified Cdc27^L7123 double mutant shows cells arrested at metaphase at a comparable frequency to the Cdc27^L7123 mutant alone. Moreover, the high frequency of anaphases seen in the BubR1^unspecified mutant as a result of the malfunctioning checkpoint is replaced in the double mutant by an elevated frequency of metaphase-like figures typical of Cdc27^L7123. The appearance of mitotic figures in squashed preparations of BubR1^unspecified Cdc27^L7123 is indistinguishable from those seen in Cdc27^L7123 alone.

(Deak et al., 2003)

Xenogenetic Interactions

Statement

Reference

(Royou et al., 2005)

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (2)

Reported As

Symbol Synonym

Bub1^unspecified

BubR1^unspecified

Name Synonyms

Secondary FlyBase IDs

References (5)

Report Sections

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