FlyBase Allele Report: Dmel\schlank[G0061]

General Information

Symbol

Dmel\schlank^G0061

Species

D. melanogaster

Name

FlyBase ID

FBal0096838

Feature type

allele

Associated gene

Dmel\schlank

Associated Insertion(s)

P{lacW}schlank^G0061

Carried in Construct

Key Links

Genomic Maps

JBrowse

Allele class

Mutagen

P-element activity

Nature of the Allele

Allele class

Mutagen

P-element activity

(Schäfer et al., 1999.3.29)

Progenitor genotype

Associated Insertion(s)

P{lacW}schlank^G0061

Cytology

Description

Allele components

Component

Use(s)

Inserted element

P{lacW}

enhancer trap

Encoded product / tool

lacZ

reporter enzyme

Tagged with

Tag:NLS(P)

nuclear protein localization tag

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

transposable_element_insertion_site

X:6,266,555..6,266,836 [-]

(Ziegler et al., 2025, Hull et al., 2024, Peter et al., 2002, Schäfer et al., 1999.3.29, Schäfer et al., 1999.6.15)

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

AJ426710

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 1 )

Disease

Interaction

References

exacerbates neuronal ceroid lipofuscinosis

modeled by cathD¹

(Kuronen et al., 2009)

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

abnormal developmental rate | larval stage

(Bauer et al., 2009)

abnormal neuroanatomy | larval stage (with schlank^G0489)

(Huang et al., 2018)

decreased body size | larval stage

(Bauer et al., 2009)

lethal

(Bauer et al., 2009)

lethal | recessive

(Schäfer et al., 1999.3.29)

lethal - all die before end of P-stage

(Peter et al., 2002)

some die during pharate adult stage

(Peter et al., 2002)

Phenotype Manifest In

embryonic/larval neuromuscular junction (with schlank^G0489)

(Huang et al., 2018)

terminal bouton | larval stage (with schlank^G0489)

(Huang et al., 2018)

Detailed Description

Statement

Reference

schlank^G0489/schlank^G0061 larvae have significantly reduced bouton number and significantly increased bouton size at the neuromuscular junction of muscle 4, compared to controls.

(Huang et al., 2018)

Hemizygous mutants are developmentally delayed, but they do reach the third instar and a fraction thereof do pupariate. Third instars are much slimmer and somewhat transparent compared to controls.

(Bauer et al., 2009)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

NOT Suppressor of

Statement

Reference

schlank^G0061 is a non-suppressor of abnormal eye color phenotype of Hsap\BCL2L13^UAS.cNa, Scer\GAL4^GMR.PS

(Nakazawa et al., 2016)

Phenotype Manifest In

Enhancer of

Statement

Reference

schlank[+]/schlank^G0061 is an enhancer of eye phenotype of cathD¹

(Kuronen et al., 2009)

Additional Comments

Genetic Interactions

Statement

Reference

Xenogenetic Interactions

Statement

Reference

The loss of pigment in the eye phenotype induced by expression of Hsap\BCL2L13^Scer\UAS.cNa driven by Scer\GAL4^GMR.PS is not suppressed by schlank^G0061. schlank^G0061 does not result in significant eye phenotypes in Scer\GAL4^GMR.PS>Hsap\BCL2L13^{ΔTM.Scer\UAS} flies.

(Nakazawa et al., 2016)

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (1)

Bloomington

11665

w^67c23 P{lacW}schlank^G0061/FM7c

Notes on Origin

Discoverer

Comments

P{lacW} not verified as causing the lethality.

(Schäfer et al., 1999.3.29)

Defined as a 'weak' allele.

(Bauer et al., 2009)

External Crossreferences and Linkouts ( 1 )

Crossreferences

GenBank Nucleotide - A collection of sequences from several sources, including GenBank, RefSeq, TPA, and PDB.

AJ426710

Synonyms and Secondary IDs (6)

Reported As

Symbol Synonym

Lag1^G0061

(Christensen et al., 2008.10.20)

Schlank^G0061

(Hull et al., 2024)

cerS^P61

(Ziegler et al., 2025)

l(1)G0061

(Peter et al., 2002)

l(1)G0061^G0061

(Schäfer et al., 1999.3.29, Schäfer et al., 1999.6.15)

schlank^G0061

(Huang et al., 2018, Sociale et al., 2018, Nakazawa et al., 2016, Voelzmann et al., 2016, Bauer et al., 2009)

Name Synonyms

Secondary FlyBase IDs

References (12)

Report Sections

Open Close