FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\eveE+L.8.4
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General Information
Symbol
Dmel\eveE+L.8.4
Species
D. melanogaster
Name
FlyBase ID
FBal0096961
Feature type
allele
Associated gene
Dmel\eve
Associated Insertion(s)
Carried in Construct
P{E+L-eve.8.4.G}
P{E+L-eve.8.4}
Key Links
Transgenic product class
wild_type
(Fujioka et al., 1999)
Mutagen
Nature of the Allele
Transgenic product class
wild_type
(Fujioka et al., 1999)
Mutagen
in vitro construct
(Fujioka et al., 1999, Sackerson et al., 1999)
Progenitor genotype
eveE+L
(Fujioka et al., 1999)
Carried in construct
P{E+L-eve.8.4.G}
P{E+L-eve.8.4}
Cytology
Description

The region 1.8kb to 8.4kb (measured from the start of eve transcription) is fused downstream of the eve coding region, restoring contiguous DNA from -6.4kb to +8.4kb as in the genome.

(Fujioka et al., 1999)

14.8kb genomic fragment containing eve sequences from -6.4kb to +8.4kb relative to the transcription start site.

(Sackerson et al., 1999)
Allele components
Component
Use(s)
Regulatory region(s)
eve
Encoded product / tool
eve
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Embryos carrying two copies of eveE+L.8.4 in a wild-type background have abnormally wide odd-numbered parasegments.

      (Kobayashi et al., 2001)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference

      The degree of rescue of the eve3 embryonic phenotype conferred by one copy of eveE+L.8.4 is reduced if the mother is heterozygous for groE48.

      (Kobayashi et al., 2001)
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Rescues

      eveE+L.8.4 rescues eve3/Df(2R)eve

      (Kobayashi et al., 2001)

      eveE+L.8.4 rescues eve3

      (Kobayashi et al., 2001)
      Partially rescues

      eveE+L.8.4 partially rescues eve1

      (Fujioka et al., 1999)

      eveE+L.8.4 partially rescues eve3

      (Fujioka et al., 1999)

      eveE+L.8.4 partially rescues eve3

      (Sackerson et al., 1999)
      Comments

      Rescues viability of eve3 homozygotes to between 15.8% and 32.3% (depending on insertion site). Hatching rate of rescued embryos is around 61%-67%, depending on site of insertion. Cuticle of single copy rescue transgenes show a high frequency of defects characteristic of hypomorphic eve mutants. Rescues viability of eve3 hemizygotes to between 21.3% and 35.6% (depending on insertion site). Hatching rate of rescued embryos is around 54%-75%, depending on site of insertion. Cuticle of single copy rescue transgenes show a high frequency of defects characteristic of hypomorphic eve mutants. Rescues viability of eve1 hemizygotes to between 18.5% and 33.1% (depending on insertion site). Cuticle of single copy rescue transgenes show a high frequency of defects characteristic of hypomorphic eve mutants.

      (Fujioka et al., 1999)

      Two copies of eveE+L.8.4 rescue eve3 to adulthood with poor fertility (one copy of eveE+L.8.4 is generally not sufficient to rescue eve3 to viability).

      (Sackerson et al., 1999)
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (1)
      Reported As
      Symbol Synonym
      eveE+L.8.4
      Name Synonyms
      Secondary FlyBase IDs
        References (4)