FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Mmus\Hoxa2hs.PP
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General Information
Symbol
Mmus\Hoxa2hs.PP
Species
M. musculus
Name
heat shock construct of Percival-Smith
FlyBase ID
FBal0097218
Feature type
allele
Associated gene
Mmus\Hoxa2
Associated Insertion(s)
Carried in Construct
P{hs-Mmus\Hoxa2.P}
Transgenic product class
wild_type
(Percival-Smith and Bondy, 1999)
Mutagen
Nature of the Allele
Transgenic product class
wild_type
(Percival-Smith and Bondy, 1999)
Mutagen
in vitro construct
(Percival-Smith and Bondy, 1999)
Progenitor genotype
Carried in construct
P{hs-Mmus\Hoxa2.P}
Cytology
Description

Construct: A heat shock promoter drives expression of Mmus\Hoxa2.

(Percival-Smith and Bondy, 1999)
Allele components
Component
Use(s)
Encoded product / tool
Mmus\Hoxa2
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Expression of Mmus\Hoxa2hs.PP using a 50 minute heat shock at 5.5 hours of development results in a weak reduction of the T1 beard; reduction of the T1 beard to less than or equal to 5 rows of denticles occurs in 38% of first instar larvae.

      (Percival-Smith and Bondy, 1999)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Suppressor of
      NOT Suppressor of
      Statement
      Reference

      Mmus\Hoxa2hs.PP is a non-suppressor of T1 beard | ectopic phenotype of Mmus\Hoxa5hs.PZ

      (Percival-Smith and Bondy, 1999)
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference

      Expression of Scrhs.PP using a 50 minute heat shock at 5.5 hours of development results in 72% of first instar larvae having an ectopic T1 beard in thoracic segment T2 and/or T3. This phenotype is suppressed by coexpression of Mmus\Hoxa2hs.PP (41% of larvae have ectopic T1 beards). Expression of Mmus\Hoxa5hs.PZ using a 50 minute heat shock at 5.5 hours of development results in 98% of first instar larvae having an ectopic T1 beard in thoracic segment T2 and/or T3. This phenotype is not suppressed by coexpression of Mmus\Hoxa2hs.PP. Ectopic expression of Mmus\Hoxa2hs.PP during larval development results in a weak twisted leg phenotype, with twisting or spiralling along the proximal distal axis of the leg.

      (Percival-Smith and Bondy, 1999)
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (2)
      Reported As
      Symbol Synonym
      Mmus\Hoxa2hs.PP
      Name Synonyms
      heat shock construct of Percival-Smith
      (Percival-Smith and Bondy, 1999)
      Secondary FlyBase IDs
        References (1)