FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Mmus\Hoxa5hs.PZ
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General Information
Symbol
Mmus\Hoxa5hs.PZ
Species
M. musculus
Name
heat shock construct of Zhao
FlyBase ID
FBal0097216
Feature type
allele
Associated gene
Associated Insertion(s)
Carried in Construct
Transgenic product class
Nature of the Allele
Transgenic product class
Progenitor genotype
Carried in construct
Cytology
Description

The full length Mmus\Hoxa5 open reading frame is expressed under the control of an Hsp70 promoter.

Allele components
Component
Use(s)
Regulatory region(s)
Encoded product / tool
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DNA sequence
Protein sequence
 
Expression Data
Reporter Expression
Additional Information
Statement
Reference
 
Marker for
Reflects expression of
Reporter construct used in assay
Human Disease Associations
Disease Ontology (DO) Annotations
Models Based on Experimental Evidence ( 0 )
Disease
Evidence
References
Modifiers Based on Experimental Evidence ( 0 )
Disease
Interaction
References
Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
 
Disease-implicated variant(s)
 
Phenotypic Data
Phenotypic Class
Phenotype Manifest In
Detailed Description
Statement
Reference

Expression of Mmus\Hoxa5hs.PZ using a 50 minute heat shock at 5.5 hours of development results in 98% of first instar larvae having an ectopic T1 beard in thoracic segment T2 and/or T3.

Expression of Mmus\Hoxa5hs.PZ using a 1 hour heat shock at 5.5-6.5 hours of development results in Scr-like transformations. Characteristically, thoracic segments T2 and T3 are transformed towards T1; the ventral beard, normally only found in segment T1, is seen in the T2 and T3 segments. Failure of head involution is seen and many cuticular head structures, such as the epistomal sclerite, ectostomal and hypostomal sclerites, H-piece, mouth hooks and sensory organs, are absent or misplaced. No transformation of the cuticle pattern is detectable in the abdominal segments. Ectopic expression of Mmus\Hoxa5hs.PZ during the larval stages using multiple heat shocks produces Scr-like transformations in the external head structures of adult flies. The abnormalities include reduced and irregular compound eyes, malformation of the mouth parts, thickening of the arista, a Ctx-like transformation in the hindhead, splitting of the maxillary palps into two segments and transformation of the antenna to leg. Structures resembling sex comb teeth are occasionally seen on the transformed antennal legs.

External Data
Interactions
Show genetic interaction network for Enhancers & Suppressors
Phenotypic Class
Phenotype Manifest In
NOT suppressed by
Statement
Reference
Additional Comments
Genetic Interactions
Statement
Reference
Xenogenetic Interactions
Statement
Reference

The Mmus\Hoxa5hs.PZ ectopic T1 beard phenotype is not suppressed by coexpression of pbhs.PP or Mmus\Hoxa2hs.PP.

Complementation and Rescue Data
Comments
Images (0)
Mutant
Wild-type
Stocks (0)
Notes on Origin
Discoverer
External Crossreferences and Linkouts ( 0 )
Synonyms and Secondary IDs (2)
Reported As
Symbol Synonym
Mmus\Hoxa5hs.PZ
Name Synonyms
heat shock construct of Zhao
Secondary FlyBase IDs
    References (2)